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首页> 外文期刊>The European Journal of Neuroscience >Postnatal development of temporal integration, spike timing and spike threshold regulation by a dendrotoxin-sensitive K+ current in rat CA1 hippocampal cells
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Postnatal development of temporal integration, spike timing and spike threshold regulation by a dendrotoxin-sensitive K+ current in rat CA1 hippocampal cells

机译：在大鼠CA1海马细胞中，Temonal Integration的产后开发，尖峰定时和尖峰定时和尖峰阈值调节

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Spike timing and network synchronization are important for plasticity, development and maturation of brain circuits. Spike delays and timing can be strongly modulated by a low-threshold, slowly inactivating, voltage-gated potassium current called D-current (ID). ID can delay the onset of spiking, cause temporal integration of multiple inputs, and regulate spike threshold and network synchrony. Recent data indicate that ID can also undergo activity-dependent, homeostatic regulation. Therefore, we have studied the postnatal development of ID-dependent mechanisms in CA1 pyramidal cells in hippocampal slices from young rats (P7-27), using somatic whole-cell recordings. At P21-27, these neurons showed long spike delays and pronounced temporal integration in response to a series of brief depolarizing current pulses or a single long pulse, whereas younger cells (P7-20) showed shorter discharge delays and weak temporal integration, although the spike threshold became increasingly negative with maturation. Application of α-dendrotoxin (α-DTX), which blocks ID, reduced the spiking latency and temporal integration most strongly in mature cells, while shifting the spike threshold most strongly in a depolarizing direction in these cells. Voltage-clamp analysis revealed an α-DTX-sensitive outward current (ID) that increased in amplitude during development. In contrast to P21-23, ID in the youngest group (P7-9) showed smaller peri-threshold amplitude. This may explain why long discharge delays and robust temporal integration only appear later, 3 weeks postnatally. We conclude that ID properties and ID-dependent functions develop postnatally in rat CA1 pyramidal cells, and ID may modulate network activity and plasticity through its effects on synaptic integration, spike threshold, timing and synchrony. Spike timing and network synchronization are important for plasticity, development and maturation of brain circuits. Spike delays and timing can be strongly modulated by a low-threshold, slowly inactivating, voltage-gated K+ current called D-current (ID). We found that ID properties and ID-dependent functions develop postnatally in rat CA1 pyramidal cells, and ID may modulate network activity and plasticity through its effects on synaptic integration, spike threshold, timing and synchrony.
机译：尖峰定时和网络同步对于脑电路的可塑性，开发和成熟是重要的。尖峰延迟和定时可以通过低阈值强烈调节，慢慢灭活，电压门控钾电流称为D-电流（ID）。 ID可以延迟尖峰的开始，导致多个输入的时间集成，并调节尖峰阈值和网络同步。最近的数据表明ID还可以接受依赖活动的稳态监管。因此，我们研究了使用体细胞全部细胞记录的来自幼鼠（P7-27）的海马切片中Ca1金字塔细胞中的ID依赖机制的出生后发展。在P21-27，这些神经元显示出长尖峰延迟并响应于一系列简短的电流脉冲或单长脉冲，而年轻的细胞（P7-20）显示出较短的放电延误和弱时间集成，虽然成熟的尖峰阈值越来越消极。 α-树突毒素（α-DTX）的施用，其块ID，降低成熟细胞中最强烈的尖峰等待时间和时间积分，同时在这些细胞中最强烈地沿偏振方向移动尖峰阈值。电压钳分析显示了在发育过程中增加的α-DTX敏感的向外电流（ID）。与P21-23相比，最小组中的ID（P7-9）显示出较小的PERI阈值幅度。这可以解释为什么在后期3周后，仅在后期出现了长的放电延迟和强大的时间集成。我们得出结论，ID属性和ID依赖功能在大鼠CA1金字塔型电池中出现后发育，ID可以通过其对突触积分，尖峰阈值，时序和同步的影响来调节网络活动和可塑性。尖峰定时和网络同步对于脑电路的可塑性，开发和成熟是重要的。尖峰延迟和定时可以通过低阈值强烈调制，慢慢灭活，电压门控K +电流被称为D电流（ID）。我们发现ID属性和ID依赖功能在大鼠CA1金字塔型电池中出现后发育，ID可以通过对突触积分，尖峰阈值，时序和同步的影响来调制网络活动和可塑性。

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