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首页> 外文期刊>The European Journal of Neuroscience >The role of the nucleus accumbens in learned approach behavior diminishes with training
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The role of the nucleus accumbens in learned approach behavior diminishes with training

机译：核心尿道在学习方法的作用与培训减少了

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Nucleus accumbens dopamine plays a key role in reward-directed approach. Past findings suggest that dopamine's role in the expression of learned behavior diminishes with extended training. However, little is known about the central substrates that mediate the shift to dopamine-independent reward approach. In the present study, rats approached and inserted the head into a reward compartment in response to a cue signaling food delivery. On days 4 and 5 of 28-trial-per-day sessions, D1 receptor antagonist R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH23390) infused to the NAc core reduced the probability and speed of cued approach. The disruptive effect of D1 receptor blockade was specific to the nucleus accumbens core and not seen with drug infusions to nearby dopamine target regions. In rats that received drug infusions after extended training (days 10 or 11), accumbens core D1 receptor blockade produced little effect on the expression of the same behavior. These results could have been due to a continued accumbens mediation of cued approach even after the behavior had become independent of accumbens D1 receptors. However, accumbens core ionotropic glutamate receptor blockade disrupted cued approach during early but not late stages of training, similar to the effects of D1 antagonist infusions. The results suggest that with extended training, a nucleus accumbens D1-dependent behavior becomes less dependent not only on nucleus accumbens D1 transmission but also on excitatory transmission in the nucleus accumbens. These findings fill an important gap in a growing literature on reorganization of striatal function over the course of training.
机译：Nucleumens多巴胺在奖励定向方法中起着关键作用。过去的调查结果表明，多巴胺在表达学习行为中的作用减少了扩展培训。然而，关于中央衬底知之甚少，该基材介导转移到多巴胺无关的奖励方法。在本研究中，大鼠接近并将头部插入奖励室，以响应提示信号传递食物递送。在28天 - 试日疗程的第4天和第5天，D1受体拮抗剂R（+） - 7-氯-8-羟基-3-甲基-1-苯基-2,3,4,5-四氢-1h -3-苯并嗪盐酸盐（SCH23390）注入NAC核心降低了CUED方法的概率和速度。 D1受体阻滞的破坏性效果对核心核心核心特异性，并且没有用药物输注到附近的多巴胺靶区域。在延长培训后接受药物输注的大鼠（第10或11天），厌核核心D1受体阻断对相同行为的表达产生的影响很小。这些结果可能是由于仍然在行为依赖于对昔韦达D1受体的情况下持续的对抗方法的调解。然而，期间核心核心离子型谷氨酸受体阻断在早期但不是晚期训练的后期造成次调节方法，类似于D1拮抗剂输注的影响。结果表明，随着延长的训练，不仅核心D1依赖性的核心D1依赖性的行为不仅依赖于核，而且还依赖于核心常规，而且依赖于细胞核尿核。这些调查结果填补了在培训过程中重组的日益增长的文献中的一个重要差距。

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