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首页> 外文期刊>The European Journal of Neuroscience >Modulation of task‐related cortical connectivity in the acute and subacute phase after stroke
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Modulation of task‐related cortical connectivity in the acute and subacute phase after stroke

机译：冲程后急性和亚急性相位中任务相关皮质连通性的调节

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Abstract The functional relevance of cortical reorganization poststroke is still not well understood. In this study, we investigated taskspecific modulation of cortical connectivity between neural oscillations in key motor regions during the early phase after stroke.EEG andEMG recordings were examined from 15 patients and 18 controls during a precision grip task using the affected hand. Each patient attended two sessions in the acute and subacute phase (median of 3 and 34?ys) poststroke. Dynamic causal modelling (DCM ) for induced responses was used to investigate taskspecific modulations of oscillatory couplings in a bilateral network comprising supplementary motor area (SMA ), dorsal premotor cortex (PM d) and primary motor cortex (M1). Fourteen models were constructed for each subject, and the input induced by the experimental manipulation (task) was set to inferior parietal lobule (IPL ). Bayesian model selection favoured a fully connected model. A reduced coupling fromSMA and intact M1 in the 齜and (3148込) to lesioned M1 in the 齜and (1530込) was observed in patients in the acute phase compared to controls. Behavioural performance improved significantly in the subacute phase, while an increased positive coupling from intactPM d to lesioned M1 and a less negative modulation from lesioned M1 to intact M1 were observed for patients compared to controls both from the 齜and to the 齜and. We infer that the observed differences in crossfrequency cortical interactions are important for functional recovery.
机译：摘要皮质重组失败的功能相关性仍然没有很好地理解。在这项研究中，我们研究了在使用受影响的手中的15名患者中检查了在早期阶段的关键电机区域中神经振荡之间的神经振荡之间的皮质连通性的任务调节。每位患者患上急性和亚急性期的两次会话（3和34岁的中位数）失败。用于诱导响应的动态因果模型（DCM）用于研究包括补充电动机面积（SMA），背部热球皮质（PM D）和初级电机皮质（M1）的双边网络中振荡耦合的TASKSPecific调制。为每个受试者构建了十四种模型，并且通过实验操作（任务）引起的输入被设定为下顶叶（IPL）。贝叶斯模型选择有利于完全连接的模型。与对照相比，在急性期患者中观察到χ和（3148‰）中的χ和（3148‰）中的χ和（3148‰）中的致损伤M1的促成M1。对于血清阶段的亚静脉期相比，对于患者，观察到从β和β和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅳ和Ⅵ和Ⅳ和损伤的M1增加了从损伤M1的损伤M1的阳性耦合和从损伤M1的较薄的阴性调节的增加。我们推断观察到的跨性皮质相互作用的差异对于功能恢复很重要。

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