...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Task‐dependent function of striatal cholinergic interneurons in behavioural flexibility
【24h】

Task‐dependent function of striatal cholinergic interneurons in behavioural flexibility

机译：纹胆碱能Interneurons在行为灵活性中的任务依赖性功能

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Flexible switching of behaviours depends on integrative functioning through the neural circuit connecting the prefrontal cortex and the dorsomedial striatum (DMS ). Although cholinergic interneurons modulate striatal outputs by diverse synaptic mechanisms, the roles of cholinergic interneurons in theDMS appear to vary among different models used to validate behavioural flexibility. Here, we conducted immunotoxinmediated cell targeting ofDMS cholinergic interneurons and examined the functions of these interneurons in behavioural flexibility, with the learning conditions differing in trial spacing and discrimination type in a modified Tmaze. Elimination of theDMS cholinergic cell group normally spared reversal learning in place discrimination with an intertrial interval (ITI ) of 15, but it impaired the reversal performance in response discrimination with the sameITI . In contrast,DMS cholinergic elimination resulted in enhanced reversal performance in both place and response discrimination tasks with a 10minITI and accelerated the reversal of response discrimination with a 20minITI . Our previous study also showed an enhanced influence of cholinergic targeting on place reversal learning with a 20minITI , and the present results demonstrate thatDMS cholinergic interneurons act to inhibit both place and response reversal performance with a relatively longerITI , whereas their functions differ between types of reversal performance in the tasks with a shorterITI . These findings suggest distinct roles of theDMS cholinergic cell group in behavioural flexibility dependent on the trial spacing and discrimination type constituting the learning tasks.
机译：摘要行为的灵活切换取决于通过连接前额叶皮质和背体纹状体（DMS）的神经电路的整合功能。虽然Cholinergic Interneurons通过多样化的突触机制调节纹状体输出，但胆碱能Interceurons在用于验证行为灵活性的不同模型中似乎不同。在此，我们进行了免疫毒素介导的细胞靶向OFDMS Cholinergic Internuolons，并在行为灵活性中检查了这些中间核心的功能，并且在修饰的Tmaze中的试验间隔和辨别类型的学习条件不同。消除氯吡啶能细胞组通常保留逆转学习，其与15的界面间隔（ITI）的歧视，但它损害了与果实响应歧视的逆转性能。相比之下，DMS Cholinergic消除导致两种地方的逆转性能提高，响应歧视任务与10miniti的响应歧视任务，并加快了20miniti的逆转判断。我们以前的研究还表明，胆碱能靶向对逆转学习的逆转学习与20miniti的逆转学习的影响提高，并且目前的结果表明，胆碱能Interneurons采用相对更长的时间来抑制其次和响应逆转性能，而其功能在逆转性能之间存在不同在短短的任务中。这些研究结果表明，依赖于依赖于构成学习任务的试验间隔和辨别类型的行为灵活性中的不同作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号