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首页> 外文期刊>The European Journal of Neuroscience >Drebrin E regulates neuroblast proliferation and chain migration in the adult brain
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Drebrin E regulates neuroblast proliferation and chain migration in the adult brain

机译：堤防e调节成年脑中的神经细胞增殖和链迁移

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F-actin-binding protein drebrin has two major isoforms: drebrin A and drebrin E. Drebrin A is the major isoform in the adult brain and is highly concentrated in dendritic spines, regulating spine morphology and synaptic plasticity. Conversely, drebrin E is the major isoform in the embryonic brain and regulates neuronal morphological differentiation, but it is also expressed in neurogenic regions of the adult brain. The subventricular zone (SVZ) is one of the brain regions where adult neurogenesis occurs. Neuroblasts migrate to the olfactory bulb (OB) and integrate into existing neuronal networks, after which drebrin expression changes from E to A, suggesting that drebrin E plays a specific role in neuroblasts in the adult brain. Therefore, to understand the role of drebrin E in the adult brain, we immunohistochemically analyzed adult neurogenesis using drebrin-null-mutant (DXKO) mice. In DXKO mice, the number of neuroblasts and cell proliferation decreased, although cell death remained unchanged. These results suggest that drebrin E regulates cell proliferation in the adult SVZ. Surprisingly, the decreased number of neuroblasts in the SVZ did not result in less neurons in the OB. This was because the survival rate of newly generated neurons in the OB increased in DXKO mice. Additionally, when neuroblasts reached the OB, the change in the migratory pathway from tangential to radial was partly disturbed in DXKO mice. These results suggest that drebrin E is involved in a chain migration of neuroblasts.
机译：F-肌动蛋白结合蛋白滴虫有两个主要同种型：翅膀A和翅膀E.翅膀A是成年脑中的主要同种型，在树突状刺，调节脊柱形态和突触塑性高度浓缩。相反，翅膀e是胚胎脑中的主要同种型，并调节神经元形态分化，但也表达了成年脑的神经发生区域。子心房区（SVZ）是成年神经发生发生的大脑区域之一。神经细胞迁移到嗅灯泡（OB）并融入现有的神经元网络中，之后捕获从e至a的河豚表达发生变化，表明堤防E在成人脑中的神经细胞中起特定作用。因此，要了解堤防e在成年脑中的作用，我们使用滴虫 - 突变体（DXKO）小鼠免疫组织化学分析成年神经发生。在DXKO小鼠中，神经细胞和细胞增殖的数量降低，但细胞死亡保持不变。这些结果表明，堤防E调节成人SVZ中细胞增殖。令人惊讶的是，SVZ中的神经细胞数量减少并未导致OB中的神经元较少。这是因为在DXKO小鼠中，新生成神经元的存活率增加。另外，当神经细胞到达OB时，在DXKO小鼠中部分地干扰了从切向径向的迁移途径的变化。这些结果表明，堤防E涉及神经细胞的链迁移。

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