...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Feeding during the rest phase promotes circadian conflict in nuclei that control energy homeostasis and sleep–wake cycle in rats
【24h】

Feeding during the rest phase promotes circadian conflict in nuclei that control energy homeostasis and sleep–wake cycle in rats

机译：在静止阶段期间喂养促进核的核核，该核核心在大鼠中控制能量稳定性和睡眠唤醒循环

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Abstract Food intake during the rest phase promotes circadian desynchrony, which has been associated with metabolic diseases. However, the link between circadian rhythm and metabolic alterations is not well understood. To investigate this issue, we explored the circadian rhythm of cFos immunoreactivity (IR) in rats fed during the day, during the night or with free access to food for 3爓eeks. The analysis was focused on the hypothalamic nuclei, which are interconnected and involved in the control of energy homeostasis and/or arousal: lateral hypothalamus (LH ), perifornical area, arcuate, ventrolateral preoptic (VLPO) and tuberomammillary nuclei. The results show that food intake during the rest phase flattened the circadian cFos expression in theLH and perifornical area, and induced a phase shift in the VLPO area. In addition, cFos expression was analyzed in the orexin and melaninconcentrating hormone (MCH) neurons of theLH , which are involved in the control of food intake and arousal, and in ?melaninstimulating hormone and neuropeptide Y (NPY) cells in the arcuate nucleus, all of which are involved in feedingfasting cycles, energy homeostasis and sending projections to theLH . The results indicate that feeding during the rest phase decreased orexin neuron activation in the light in comparison with the other groups. Feeding during this phase also flattened the activity rhythm of MCH and ?melaninstimulating hormone neurons and increased NPY IR when the light was turned on. This evidence indicates that mealtime differentially affected the hypothalamic nuclei under investigation leading to a circadian conflict that might account for metabolic impairment.
机译：摘要在休息期间的食物摄入量促进了与代谢疾病有关的昼夜活动。但是，昼夜节律和代谢改变之间的联系并不充分了解。为了调查这个问题，我们探讨了在当天喂养的大鼠中的CFOS免疫反应性（IR）的昼夜节律，夜间或免费获得3岁eeks的食物。该分析重点是丘脑核，其互连并涉及能量稳态和/或唤醒的控制：外侧下丘脑（LH），垂直的区域，弧形，腹外侧疗程（VLP）和Tuberocillary核。结果表明，在静物相期间的食物摄入量展平了大核和围绕地区的昼夜CFO表达，并在VLPO区域诱导相移。此外，CFOS表达在甲素蛋白和黑色素浓缩的激素（MCH）神经元（MCH）神经元中分析，所述rhelh涉及食物摄入和唤醒的控制，以及在弓形核中的α黑色素治疗激素和神经肽Y（npy）细胞中的所有其中涉及饲喂周围的循环，能量稳态和向塞尔发送突起。结果表明，与其他基团相比，在静物相期间喂食尿素蛋白神经元活化。在该阶段期间喂养也展平了MCH的活性节律和α黑色素激素神经元，并且当光线导通时，NPY IR增加。这一证据表明，膳食时间差异地影响了调查下的下丘脑核，导致可能考虑到代谢损伤的昼夜冲突。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号