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首页> 外文期刊>The European Journal of Neuroscience >Neural coding of the sound envelope is changed in the inferior colliculus immediately following acoustic trauma
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Neural coding of the sound envelope is changed in the inferior colliculus immediately following acoustic trauma

机译：声学包络的神经编码在声学创伤后立即改变在劣质小学中

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摘要

Sensorineural hearing loss is often accompanied by difficulties with understanding speech in fluctuating backgrounds, suggesting that neural coding of complex sound features, such as the sound envelope, is impaired. Here, we studied how temporal and rate coding of the envelope is affected in the inferior colliculus immediately after acoustic trauma. Neural activity in response to amplitude-modulated noise was -recorded from the inferior colliculus of the guinea pig, before and immediately after a 1-hr 11-kHz acoustic trauma. Units with a characteristic frequency (CF) below the trauma frequency ( 11 kHz, which had large acoustic trauma-induced threshold shifts, had decreased response gains to amplitude-modulated noise. Shapes of temporal modulation transfer functions shifted toward a higher proportion of low-pass shapes in low-CF units, and to less band-pass shapes in high-CF units. Furthermore, driven firing rates decreased, especially at high modulation frequencies for high-CF units. The observed changes occurred immediately following trauma and were thus a result of the immediate trauma-induced damage to the auditory system. If also present in human subjects, reduced response gains in high-frequency units could disrupt coding of consonants and consequently impair speech understanding in noisy environments. Moreover, the enhanced temporal coding by low-CF units of the low modulation frequencies could overly amplify responses to low-frequency noise, further deteriorating listening in noise.
机译：感觉文体听力损失通常伴随着对波动背景中的言论造成的困难，这表明复杂声音特征的神经编码，例如声音包络被损害。在这里，我们研究了信封的时间和速率编码如何在声学创伤后立即受到劣质小的较差的。在1小时11-KHz声学创伤之后，从豚鼠的下小粒子响应响应幅度调节噪声的神经活动。具有以下创伤频率的特征频率（CF）的单位（具有大的声学创伤引起的阈值偏移的11 kHz，对幅度调制噪声降低了响应增益。时间调制传递函数的形状朝向更高的低比例转移在低CF单元中通过形状，并以高CF单元的较少的带通形状。此外，驱动的烧制率降低，特别是高CF单位的高调制频率。观察到的变化在创伤后立即发生，因此是一个即时创伤造成对听觉系统的损伤的结果。如果也存在于人类的主题中，高频单元的减少响应增益可能会破坏辅音的编码，因此在嘈杂的环境中损害语音理解。此外，低的时间-CF的低调制频率单位可能会过度放大对低频噪声的响应，进一步恶化噪音。

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