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首页> 外文期刊>The European Journal of Neuroscience >Spontaneous eye blink rate and dopamine synthesis capacity: preliminary evidence for an absence of positive correlation
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Spontaneous eye blink rate and dopamine synthesis capacity: preliminary evidence for an absence of positive correlation

机译：自发眼眨眼率和多巴胺合成能力：缺乏正相关的初步证据

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摘要

Dopamine is central to a number of cognitive functions and brain disorders. Given the cost of neurochemical imaging in humans, behavioural proxy measures of dopamine have gained in popularity in the past decade, such as spontaneous eye blink rate (sEBR). Increased sEBR is commonly associated with increased dopamine function based on pharmacological evidence and patient studies. Yet, this hypothesis has not been validated using in vivo measures of dopamine function in humans. To fill this gap, we measured sEBR and striatal dopamine synthesis capacity using [18F]DOPA PET in 20 participants (nine healthy individuals and 11 pathological gamblers). Our results, based on frequentist and Bayesian statistics, as well as region-of-interest and voxel-wise analyses, argue against a positive relationship between sEBR and striatal dopamine synthesis capacity. They show that, if anything, the evidence is in favour of a negative relationship. These results, which complement findings from a recent study that failed to observe a relationship between sEBR and dopamine D2 receptor availability, suggest that caution and nuance are warranted when interpreting sEBR in terms of a proxy measure of striatal dopamine
机译：多巴胺是许多认知功能和脑疾病的核心。鉴于人类中神经化学成像的成本，在过去十年中，多巴胺的行为代理措施在普及中获得了普及，例如自发眼睛眨眼率（SEBR）。增加的SEBR通常与基于药理证据和患者研究的多巴胺功能增加。然而，这种假设尚未使用人类的多巴胺函数的体内测量验证。为了填补这种差距，我们使用[18F] DOPA PET在20名参与者（九个健康个体和11个病理赌徒）中测量SEBR和纹状体多巴胺合成能力。我们的结果，基于频繁和贝叶斯统计，以及兴趣区域和体素 - 明智的分析，反对SEBR和纹状体多巴胺合成能力之间的阳性关系。他们表明，如果有的话，证据有利于负面关系。这些结果，其中最近的研究表明未能观察到SEBR和多巴胺D2受体可用性之间的关系，建议在解释SEBR时，在纹状体多巴胺的代理测量方面解释SEBR

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