...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The European Journal of Neuroscience >Nicotine and alcohol: the role of midbrain dopaminergic neurons in drug reinforcement
【24h】

Nicotine and alcohol: the role of midbrain dopaminergic neurons in drug reinforcement

机译：尼古丁和酒精：中亚多巴胺能神经元在药物增强中的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Nicotine and alcohol addiction are leading causes of preventable death worldwide and continue to constitute a huge socio-economic burden. Both nicotine and alcohol perturb the brain's mesocorticolimbic system. Dopamine (DA) neurons projecting from the ventral tegmental area (VTA) to multiple downstream structures, including the nucleus accumbens, prefrontal cortex, and amygdala, are highly involved in the maintenance of healthy brain function. VTA DA neurons play a crucial role in associative learning and reinforcement. Nicotine and alcohol usurp these functions, promoting reinforcement of drug taking behaviors. In this review, we will first describe how nicotine and alcohol individually affect VTA DA neurons by examining how drug exposure alters the heterogeneous VTA microcircuit and network-wide projections. We will also examine how coadministration or previous exposure to nicotine or alcohol may augment the reinforcing effects of the other. Additionally, this review briefly summarizes the role of VTA DA neurons in nicotine, alcohol, and their synergistic effects in reinforcement and also addresses the remaining questions related to the circuit-function specificity of the dopaminergic system in mediating nicotine/alcohol reinforcement and comorbidity.
机译：尼古丁和酒精成瘾是全世界可预防死亡的主要原因，并继续构成巨大的社会经济负担。尼古丁和酒精都扰乱了大脑的中皮质醇体系。从腹侧传神区域（VTA）突出到多个下游结构的多巴胺（DA）神经元，包括核心尿，前额落型皮质和Amygdala，高度涉及健康脑功能的维持。 VTA Da Neurons在联想学习和加强中发挥着至关重要的作用。尼古丁和酒精篡夺了这些功能，促进了药物的加强措施。在本综述中，我们将首先描述尼古丁和醇是如何通过检查药物暴露如何改变异质VTA微电路和网络范围的投影来单独影响VTA Da神经元。我们还将探讨共同学生或以前接触尼古丁或酒精的程度可能会增加另一个的增强效果。此外，本综述简要概述了VTA Da神经元在尼古丁，酒精和增强中的协同作用中的作用，还解决了与多巴胺能系统的电路功能特异性介导尼古丁/醇增强和合并症的剩余问题。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号