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首页> 外文期刊>The European Journal of Neuroscience >Assessment of the effect of continuous theta burst stimulation of the motor cortex on manual dexterity in non-human primates in a direct comparison with invasive intracortical pharmacological inactivation
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Assessment of the effect of continuous theta burst stimulation of the motor cortex on manual dexterity in non-human primates in a direct comparison with invasive intracortical pharmacological inactivation

机译：与侵袭性肠道药理学灭活直接比较，评估电动机皮层对非人类灵长类动物手工灵活性的影响

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摘要

Non-invasive reversible perturbation techniques of brain output such as continuous theta burst stimulation (cTBS), commonly used to modulate cortical excitability in humans, allow investigation of possible roles in functional recovery played by distinct intact cortical areas following stroke. To evaluate the potential of cTBS, the behavioural effects of this non-invasive transient perturbation of the hand representation of the primary motor cortex (M1) in non-human primates (two adult macaques) were compared with an invasive focal transient inactivation based on intracortical microinfusion of GABA-A agonist muscimol. The effects on the contralateral arm produced by cTBS or muscimol were directly compared based on a manual dexterity task performed by the monkeys, the "reach and grasp" drawer task, allowing quantitative assessment of the grip force produced between the thumb and index finger and exerted on the drawer's knob. cTBS only induced modest to moderate behavioural effects, with substantial variability on manual dexterity whereas the intracortical muscimol microinfusion completely impaired manual dexterity, producing a strong and clear cortical inhibition of the M1 hand area. In contrast, cTBS induced mixed inhibitory and facilitatory/excitatory perturbations of M1, though with predominant inhibition. Although cTBS impacted on manual dexterity, its effects appear too limited and variable in order to use it as a reliable proof of cortical vicariation mechanism (cortical area replacing another one) underlying functional recovery following a cortical lesion in the motor control domain, in contrast to potent pharmacological block generated by muscimol infusion, whose application is though limited to an animal model such as non-human primate.
机译：脑输出的非侵袭性可逆扰动技术，例如连续θ爆发刺激（CTB），通常用于调节人类中的皮质兴奋性，允许在中风后的不同完整皮质区域发挥的功能恢复中可能的作用。为了评估CTB的潜力，将初级电动机皮质（M1）在非人类原始化物（两种成人猕猴）中的这种非侵入性瞬时扰动的行为效应与基于内部的侵袭性焦瞬态失活GABA-A激动剂的微灌注。基于由猴子，“REACH和掌握”抽屉任务执行的手动灵活性任务，直接对对侧臂产生的对侧臂的影响，允许对拇指和食指之间产生的抓地力进行定量评估并施加定量评估在抽屉的旋钮上。 CTB仅诱导适度的行为效应，对手动灵活性具有大量可变性，而肠道芥子醇微灌注完全受损的手动灵活性，产生了强大明显的皮质抑制M1手区域。相比之下，CTBS诱导M1的混合抑制和促进/兴奋性/兴奋性扰动，但具有主要的抑制作用。虽然CTBS对手动灵活性影响，但其效果出现​​了过于有限和变量，以便将其作为皮质切片机制（皮质区域代替另一个）的可靠证明，其在电机控制结构域中的皮质病变之后的功能恢复潜在的功能恢复。由Muscimol Infusion产生的有效的药理学块，其应用仅限于诸如非人类灵长类动物的动物模型。

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