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首页> 外文期刊>The European Journal of Neuroscience >Deterministic fate assignment of Müller glia cells in the zebrafish retina suggests a clonal backbone during development
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Deterministic fate assignment of Müller glia cells in the zebrafish retina suggests a clonal backbone during development

机译：Zebrafish Retina中MüllerGlia细胞的确定性命运分配表明在开发过程中克隆骨干

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摘要

The optic cup houses multipotent retinal progenitor cells that proliferate and differentiate to form the mature retina, containing five main types of neurons and a single glial cell type, the M黮ler cell. Progenitors of the zebrafish optic cup generate clones that vary regarding the number and types of neurons, a process we previously showed could be described by stochastic models. Here, we present data indicating that each retinal progenitor cell, in the 24 hrs post-fertilization optic cup, is predestined to form a single M黮ler cell. This striking fate assignment of M黮ler cells reveals a dual nature of retinal lineages where stochastic mechanisms produce variable numbers of neurons while there is a strong deterministic component governing the formation of glia cells. A possible mechanism for this stereotypic fate assignment could be the maintenance of a clonal backbone during retina development, which would be similar to invertebrate and rodent cortical neurogenesis. ?2018 The Authors. European Journal of Neuroscience published by Federation of European Neuroscience Societies and JohnWiley & Sons Ltd
机译：光学杯容纳多能视网膜祖细胞，其增殖和分化形成成熟视网膜，含有五种主要类型的神经元和单一神经胶质细胞类型，M黮LER细胞。斑马鱼光杯的祖细胞产生克隆，这些克隆对神经元的数量和类型，我们以前显示的过程可以通过随机模型来描述。这里，我们存在表明每个视网膜祖细胞，在施用后的24小时后施肥光学杯中的数据预先形成单个M≥LER细胞。这种醒目的命运分配M黮LER细胞揭示了视网膜谱系的双重性质，其中随机机制产生可变数量的神经元，同时存在有胶质细胞形成的强烈确定性组分。这种刻板型命运分配的可能机制可以是视网膜开发期间克隆骨干的维持，这与无脊椎动物和啮齿动物皮质神经发生相似。 ？2018年作者。欧洲神经科学联合会发表的神经科学杂志和约翰威莱斯＆SONS LTD

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