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首页> 外文期刊>The European Journal of Neuroscience >Stress resilience evidenced by grooming behaviour and dopamine levels in male mice selected for high and low immobility using the tail suspension test
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Stress resilience evidenced by grooming behaviour and dopamine levels in male mice selected for high and low immobility using the tail suspension test

机译：使用尾悬架试验选择用于高和低的不动的雄性小鼠的梳理行为和多巴胺水平来证明应力弹性

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摘要

Grooming behaviour has different functions on many species during development and can be observed and affected during periods of stress. By selecting male mice with high (HI) and low (LI) immobility traits in the tail suspension test, a screening for antidepressant drugs, we investigate how these phenotypes associated with grooming behaviour may be influenced by the effects of repeated restraint stress. For this we used the sucrose preference test and the splash test in a novel and a familiar cage performed before and after exposure to 2 days of restraint stress. Animals were submitted to an additional day of restraint stress before the hypothalamus, prefrontal cortex and midbrain extraction for dopamine activity analysis. Corticosterone analysis was made in three distinct moments: without stress (prior first restraint session), immediately after the last restrain, and 1 hr after the last restrain episode. Compared to LI group, HI animals exhibited an increased frequency and decreased time of grooming in the familiar cage. In the novel cage, stress increased frequency and time of grooming of HI animals compared to LI. Corticosterone levels were increased in HI animals after 3 days of stress. Lower hypothalamic dopaminergic activity without stress and decreased hypothalamic dopaminergic activity immediately after stress in HI group were observed. The HI group displayed decreased prefrontal cortex dopaminergic activity and increased activity in the mesolimbic area. We proposed that through the influence of stress the two phenotypes manifested as a resilient (LI) and a not resilient (HI) trait in response to restraint stress.
机译：在开发期间，梳理行为在许多物种上具有不同的功能，并且在压力期间可以观察和影响。通过在尾悬浮试验中选择具有高（HI）和低（Li）的雄性小鼠，抗抑郁药物的筛选，我们研究了如何影响与梳理行为相关的这些表型如何受到重复约束应激的影响的影响。为此，我们使用了蔗糖偏好测试和在暴露于2天的约束应力之前和之后进行的新颖和熟悉的笼子中的溅到。在下丘脑，前额叶皮质和中脑提取的多巴胺活性分析之前，将动物提交到额外的约束应力。皮质酮分析在三个不同的时刻进行：没有压力（先前的第一个约束会议），在最后一次抑制后立即，最后一次抑制事件后1小时。与Li Group相比，HI DAMALS在熟悉的笼子里表现出频率增加和减少的梳理时间。在新的笼子里，与李相比，压力增加了喜剧院的频率和时间。在应激3天后，皮质酮水平在大动物中增加。较低的下丘脑多巴胺能活性没有压力，并且在观察HI基团中的胁迫后立即降低下丘脑多巴胺能活性。 HI组显示出预逆转性皮质多巴胺能活性和培养基区域的增加。我们提出通过应力的影响，两种表型表现为弹性（Li）和响应于约束应激的不弹性（HI）特征。

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