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首页> 外文期刊>The European Journal of Neuroscience >β‐adrenergic modulation of discrimination learning and memory in the auditory cortex
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β‐adrenergic modulation of discrimination learning and memory in the auditory cortex

机译：β-肾上腺素能调制在听觉皮层中的歧视学习和记忆

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摘要

Despite vast literature on catecholaminergic neuromodulation of auditory cortex functioning in general, knowledge about its role for long‐term memory formation is scarce. Our previous pharmacological studies on cortex‐dependent frequency‐modulated tone‐sweep discrimination learning of Mongolian gerbils showed that auditory‐cortical D1/5‐dopamine receptor activity facilitates memory consolidation and anterograde memory formation. Considering overlapping functions of D1/5‐dopamine receptors and β‐adrenoceptors, we hypothesised a role of β‐adrenergic signalling in the auditory cortex for sweep discrimination learning and memory. Supporting this hypothesis, the β1/2‐adrenoceptor antagonist propranolol bilaterally applied to the gerbil auditory cortex after task acquisition prevented the discrimination increment that was normally monitored 1 day later. The increment in the total number of hurdle crossings performed in response to the sweeps per se was normal. Propranolol infusion after the seventh training session suppressed the previously established sweep discrimination. The suppressive effect required antagonist injection in a narrow post‐session time window. When applied to the auditory cortex 1 day before initial conditioning, β1‐adrenoceptor‐antagonising and β1‐adrenoceptor‐stimulating agents retarded and facilitated, respectively, sweep discrimination learning, whereas β2‐selective drugs were ineffective. In contrast, single‐sweep detection learning was normal after propranolol infusion. By immunohistochemistry, β1‐ and β2‐adrenoceptors were identified on the neuropil and somata of pyramidal and non‐pyramidal neurons of the gerbil auditory cortex. The present findings suggest that β‐adrenergic signalling in the auditory cortex has task‐related importance for discrimination learning of complex sounds: as previously shown for D1/5‐dopamine receptor signalling, β‐adrenoceptor activity supports long‐term memory consolidation and reconsolidation; additionally, tonic input through β1‐adrenoceptors may control mechanisms permissive for memory acquisition.
机译：尽管对听觉皮层的儿茶酰胺能神经调节的巨大文献一般，但了解其长期记忆形成作用的知识是稀缺的。我们以前关于蒙古石鼠的皮质依赖频率调制音调扫描歧视学习的药理学研究表明，听觉皮质D1 / 5-多巴胺受体活性有助于记忆合并和胎盘记忆形成。考虑到D1 / 5-多巴胺受体和β-肾上腺素受体的重叠功能，我们假设β-肾上腺素能信号传导在听觉皮层中的扫描歧视学习和记忆中的作用。支持这一假设，β1/ 2-肾上腺素受体拮抗剂普萘洛尔双侧施用于任务习得后的Gerbil听觉皮层，防止了一天通常监测的歧视增量。响应于扫描本身而执行的障碍交叉总数的增量是正常的。第七次训练会议后的proPranolol输注抑制了先前建立的扫描歧视。抑制作用在狭窄的会话时间窗口中需要拮抗剂注射。当初始调节前1天施加到听觉皮质1天时，β1-肾上腺素受体拮抗和β1-肾上腺素受体刺激剂分别延迟和促​​进，扫描歧视学习，而β2选择性药物无效。相比之下，普萘洛尔输注后单扫检测学习是正常的。通过免疫组织化学，β1-和β2-肾上腺素受体鉴定在Gerbil听觉皮质的金字塔和非金字塔神经元的神经岩和躯体上。本研究结果表明，听觉皮层中的β-肾上腺素能信号与复杂声音的歧视学习有关的任务相关的重要性：如前所述，对于D1 / 5-多巴胺受体信号传导，β-肾上腺素活性活性支持长期记忆合并和重新源性;另外，通过β1-adrenceptors的滋补输入可以控制允许存储器采集的机制。

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