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首页> 外文期刊>The European Journal of Neuroscience >The COMT Val(158)Met polymorphism does not modulate the after-effect of tDCS on working memory
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The COMT Val(158)Met polymorphism does not modulate the after-effect of tDCS on working memory

机译：COMT VAL（158）MET多态性不会调制TDC在工作存储器上的后效应

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Transcranial direct current stimulation (tDCS) can alter cortical excitability, neural plasticity, and cognitive-behavioral performance; however, its effects are known to vary across studies. A partial account of this variability relates to individual differences in dopamine function. Indeed, dopaminergic manipulations alter the physiological and cognitive-behavioral effects of tDCS, and gene polymorphisms related to dopamine have predicted individual response to online tDCS (i.e., stimulation overlapping with the critical task). Notably, the role of individual differences in dopamine has not yet been properly assessed in the effect of offline tDCS (i.e., stimulation prior to the critical task). We investigated if and how the COMT Val(158)Met polymorphism (rs4680) modulates the after-effect of prefrontal tDCS on verbal working memory (WM). One hundred and thirty-nine participants were genotyped for the COMT Val(158)Met polymorphism and received anodal-over-left, cathodal-over-right (AL-CR), cathodal-over-left, anodal-over-right (CL-AR), or sham stimulation over the dorsolateral prefrontal cortex in a between-subjects, pretest-posttest study design. WM was assessed using the N-back task. The results provide no evidence that the COMT polymorphism impacts the after-effect of prefrontal tDCS on WM. Taken together with previous findings on dopamine and tDCS interactions, the results of the present study suggest that (a) indirect markers of dopamine (such as COMT) are differently related to online and offline effects of tDCS, and (b) findings from studies involving pharmacological manipulation should be generalized with caution to findings of inter-individual differences. In sum, we argue that state (i.e., a manipulation of) and trait (i.e., baseline) differences in dopamine may exert different effects on online and offline tDCS.
机译：经颅直流刺激（TDC）可以改变皮质兴奋性，神经可塑性和认知行为性能;然而，已知其影响因研究而异。这种可变性的部分叙述涉及多巴胺功能的个体差异。实际上，多巴胺能处理改变TDC的生理和认知行为效应，与多巴胺有关的基因多态性预测对在线TDC的个人反应（即，与关键任务的刺激重叠）。值得注意的是，在离线TDCS（即，关键任务之前，刺激）的效果尚未正确评估多巴胺中单个差异的作用。我们调查了Comt Val（158）符合多态性（RS4680）调制前额外TDC在口头工作存储器（WM）上的后效效应。对于COMT VAL（158）达到多态性，并且接受了多态性，并接受了左右的阴极过度（AL-CR），阴极 - 过多的右右（CL）的基因分型 - 在受试者之间的预防性研究设计中，在受试者之间的背侧前额叶皮质中，或假刺激。使用N-Back任务进行评估WM。结果没有证据表明，COMT多态性影响前额叶TDCs对WM的后效。与先前的多巴胺和TDCS相互作用一起服用，本研究结果表明（a）多巴胺（例如COMT）的间接标志物与TDCS的联机和离线效应不同，（b）涉及研究的研究结果药理学操纵应谨慎地推广，以确定个体间差异。总而言之，我们认为多巴胺的州和特质（即，基线）差异可能对网上和离线TDC进行不同的影响。

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