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首页> 外文期刊>The European physical journal, E. Soft matter >Dynamics of cooperative cargo transport by two elastically coupled kinesin motors
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Dynamics of cooperative cargo transport by two elastically coupled kinesin motors

机译：两种弹性耦合的Kinesin电机合作货物运输的动态

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.Intracellular transport is performed often by multiple motor proteins bound to the same cargo. Here, we study theoretically collective transport of the cargo by two kinesin motors. We propose that the motor has only the elastic interaction with the cargo via the linker connecting them and has no interaction with another motor. With parameters values for single motors from the available single-molecule data, we show that at linker's elastic strength K approximate to 0.25 pN/nm the theoretical data of both velocity and run length of the two-motor assembly under no load are identical to the available experimental data. The run length distribution is single exponential. The single-motor-bound state of the assembly dominates the transport. Both the force dependence of the velocity of the cargo driven by single load-bearing motor and that by two load-bearing motors in the assembly are consistent with the experimental data. The stall force of the assembly is larger than the sum of stall forces of two uncoupled motors. Moreover, we predict that the stall force increases with the increase of K and becomes saturated at large K, with the saturated value being 1.5-fold larger than the sum of stall forces of the two uncoupled motors.
机译：introcellullular常规运输通常由与同一货物结合的多个电机蛋白质进行。在这里，我们通过两个kinesin电机研究了货物的理论上集体运输。我们建议电动机仅通过连接它们的连接器具有与货物的弹性相互作用，并且与另一个电动机没有相互作用。利用来自可用单分子数据的单个电机的参数值，我们表明，在连接器的弹性强度k近似为0.25 pn / nm，两个电动机组件的无负载不均匀的速度和运行长度的理论数据与可用的实验数据。运行长度分布是单指数。组装的单电动电动机束缚状态占据了运输。由单承载电动机驱动的货物驱动的速度的力依赖性均由组件中的两个承载电动机与实验数据一致。组件的摊位力大于两个未耦合电动机的失速力的总和。此外，我们预测，停滞力随着k的增加而增加并且在大k饱和时变得饱和，饱和值比两个解耦电动机的失速力的总和大1.5倍。

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