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首页> 外文期刊>The European respiratory journal : >ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing
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ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing

机译：支气管挑战检测技术标准：间接气道挑战检测的病理生理学和方法论

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Recently, this international task force reported the general considerations for bronchial challenge testing and the performance of the methacholine challenge test, a "direct" airway challenge test. Here, the task force provides an updated description of the pathophysiology and the methods to conduct indirect challenge tests. Because indirect challenge tests trigger airway narrowing through the activation of endogenous pathways that are involved in asthma, indirect challenge tests tend to be specific for asthma and reveal much about the biology of asthma, but may be less sensitive than direct tests for the detection of airway hyperresponsiveness. We provide recommendations for the conduct and interpretation of hyperpnoea challenge tests such as dry air exercise challenge and eucapnic voluntary hyperpnoea that provide a single strong stimulus for airway narrowing. This technical standard expands the recommendations to additional indirect tests such as hypertonic saline, mannitol and adenosine challenge that are incremental tests, but still retain characteristics of other indirect challenges. Assessment of airway hyperresponsiveness, with direct and indirect tests, are valuable tools to understand and to monitor airway function and to characterise the underlying asthma phenotype to guide therapy. The tests should be interpreted within the context of the clinical features of asthma.
机译：最近，这支国际工作队报告了支气管挑战检测的一般考虑和甲素挑战试验的性能，“直接”气道挑战试验。在这里，任务力提供了对病理生理学的更新描述以及进行间接挑战测试的方法。由于间接挑战试验触发通气道通过涉及哮喘涉及哮喘的内源性途径而缩小，因此间接挑战试验往往是对哮喘的特异性，并且对哮喘的生物学揭示了大量的哮喘，但可能比检测到气道的直接测试敏感超反应性。我们为干燥空气运动挑战和eucapnic自主高核痤疮提供了对高苯核挑战测试的行为和解释的建议，为气道缩小提供了一个强大的刺激。该技术标准将建议扩展到额外的间接测试，如高渗盐水，甘露醇和腺苷挑战，这是增量测试，但仍然保持其他间接挑战的特征。通过直接和间接测试的气道高反应性评估是理解和监测气道功能的宝贵工具，并表征潜在的哮喘表型以指导治疗。测试应在哮喘临床特征的上下文中解释。

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