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首页> 外文期刊>The British Journal of Nutrition >Dietary starch promotes hepatic lipogenesis in barramundi (Lates calcarifer)
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Dietary starch promotes hepatic lipogenesis in barramundi (Lates calcarifer)

机译：膳食淀粉在Barramundi（Lates Calcarifer）促进肝脂肪生成

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摘要

Barramundi (Lates calcarifer) are a highly valued aquaculture species, and, as obligate carnivores, they have a demonstrated preference for dietary protein over lipid or starch to fuel energetic growth demands. In order to investigate how carnivorous fish regulate nutritional cues, we examined the metabolic effects of feeding two isoenergetic diets that contained different proportions of digestible protein or starch energy. Fish fed a high proportion of dietary starch energy had a higher proportion of liver SFA, but showed no change in plasma glucose levels, and few changes in the expression of genes regulating key hepatic metabolic pathways. Decreased activation of the mammalian target of rapamycin growth signalling cascade was consistent with decreased growth performance values. The fractional synthetic rate (lipogenesis), measured by TAG(2)H-enrichment using(2)H NMR, was significantly higher in barramundi fed with the starch diet compared with the protein diet (0 center dot 6 (se0 center dot 1)v. 0 center dot 4 (se0 center dot 1) % per d, respectively). Hepatic TAG-bound glycerol synthetic rates were much higher than other closely related fish such as sea bass, but were not significantly different (starch, 2 center dot 8 (se0 center dot 3)v. protein, 3 center dot 4 (se0 center dot 3) % per d), highlighting the role of glycerol as a metabolic intermediary and high TAG-FA cycling in barramundi. Overall, dietary starch significantly increased hepatic TAG through increased lipogenesis. Compared with other fish, barramundi possess a unique mechanism to metabolise dietary carbohydrates and this knowledge may define ways to improve performance of advanced formulated feeds.
机译：Barramundi（Lates Calcarifer）是一种高度重视的水产养殖种类，并且作为苛刻的食肉动物，他们对脂质或淀粉的膳食蛋白质进行了表现偏好，以燃料能量增长需求。为了调查肉食鱼类如何调节营养提示，我们检查了喂养了两种异种饮食的代谢效应，其含有不同比例的可消化蛋白质或淀粉能量。喂养高比例的膳食淀粉能量具有较高比例的肝脏SFA，但显示了血浆葡萄糖水平的变化，并且在调节关键肝代谢途径的基因表达的情况下少量变化。降低哺乳动物催乳素生长信号传导级联的哺乳动物靶标的激活与增长性能值降低一致。使用（2）H NMR通过标签（2）H富集测量的分数合成率（脂肪生成）在Barramundi与淀粉饮食相比，与蛋白质饮食相比（0中心点6（SE0 Center Dot 1）相比，饲喂淀粉饮食v.0分别为每d中心点4（SE0中心点1）％）。肝标签结合的甘油合成率远高于其他密切相关的鱼类，如鲈鱼，但没有显着差异（淀粉，2中心点8（SE0中心点3）v。蛋白质，3中心点4（SE0中心点3）每D％），突出甘油作为代谢中介和Barramundi循环的代谢中介和高标签循环的作用。总体而言，通过增加的脂肪生成，膳食淀粉显着增加肝标签。与其他鱼相比，Barramundi具有独特的机制来代谢膳食碳水化合物，并且这些知识可以定义提高先进配制饲料的性能的方法。

著录项

  • 来源
    《The British Journal of Nutrition》 |2020年第4期|共11页
  • 作者

    Wade N. M.; Trenkner L. H.; Viegas I; Tavares L. C.; Palma M.; Skiba-Cassy S.; Dias K.; Vachot C.; Araujo B. C.; Bourne N.; Blyth D.; Irvin S.; Glencross B. D.;

  • 作者单位

    Commonwealth Sci Ind Res Org CSIRO Agr &

    Food Queensland Biosci Precinct St Lucia Qld 4067 Australia;

    Commonwealth Sci Ind Res Org CSIRO Agr &

    Food Queensland Biosci Precinct St Lucia Qld 4067 Australia;

    Univ Coimbra Ctr Neurosci &

    Cell Biol CNC P-3004517 Coimbra Portugal;

    Univ Coimbra Ctr Neurosci &

    Cell Biol CNC P-3004517 Coimbra Portugal;

    Commonwealth Sci Ind Res Org CSIRO Agr &

    Food Queensland Biosci Precinct St Lucia Qld 4067 Australia;

    Inst Natl Rech Agron INRA UMR1419 Nutr Metab Aquaculture NUMEA E2S UPPA F-64310 St Pee Sur Nivelle France;

    Inst Natl Rech Agron INRA UMR1419 Nutr Metab Aquaculture NUMEA E2S UPPA F-64310 St Pee Sur Nivelle France;

    Inst Natl Rech Agron INRA UMR1419 Nutr Metab Aquaculture NUMEA E2S UPPA F-64310 St Pee Sur Nivelle France;

    Commonwealth Sci Ind Res Org CSIRO Agr &

    Food Queensland Biosci Precinct St Lucia Qld 4067 Australia;

    Commonwealth Sci Ind Res Org CSIRO Agr &

    Food Queensland Biosci Precinct St Lucia Qld 4067 Australia;

    Commonwealth Sci Ind Res Org CSIRO Agr &

    Food Bribie Isl Res Ctr Bribie Isl Qld 4507 Australia;

    Commonwealth Sci Ind Res Org CSIRO Agr &

    Food Bribie Isl Res Ctr Bribie Isl Qld 4507 Australia;

    Commonwealth Sci Ind Res Org CSIRO Agr &

    Food Queensland Biosci Precinct St Lucia Qld 4067 Australia;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 营养卫生、食品卫生;
  • 关键词

    Liver; Fish; Nutrigenomics; H-2; Lipogenic flux; NMR;

    机译：肝脏;鱼;营养素;H-2;脂肪生成助焊剂;NMR;

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