...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The British Journal of Nutrition >A single injection of vitamin D3 improves insulin sensitivity and β-cell function but not muscle damage or the inflammatory and cardiovascular responses to an acute bout of resistance exercise in vitamin D-deficient resistance-trained males
【24h】

A single injection of vitamin D3 improves insulin sensitivity and β-cell function but not muscle damage or the inflammatory and cardiovascular responses to an acute bout of resistance exercise in vitamin D-deficient resistance-trained males

机译：单一注射维生素D3可提高胰岛素敏感性和β细胞功能，但对维生素D缺乏耐受血液的抗性运动的抗抗抗性运动的抗肌肉损伤或炎症和心血管反应

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Vitamin D deficiency is now a recognised problem affecting multiple physiological functions. The aim of the present study was to evaluate the effect of a single dose of vitamin D3 injection on the inflammatory, muscular damage, metabolic and cardiovascular responses to an acute bout of resistance exercise (RE) in vitamin D-deficient resistance-trained males. Blood samples from fourteen vitamin D-deficient resistance-trained males were obtained during two separate trials: lower vitamin D (LVD) and higher vitamin D (HVD, after vitamin D3 injection). Metabolic, inflammatory, muscle damage and cardiovascular markers were evaluated at baseline, immediately and 1 h after RE. There were significant trial-by-time interactions for insulin and homeostatic model assessment of insulin resistance (HOMA-IR) which significantly (P < 0·05) declined for 1 h after RE in the HVD trial compared with the LVD trial. Homeostasis model assessment of β-cell function (HOMA-β) declines at 1 h post-RE in the HVD trial. There was also a time effect for blood sugar which significantly (P < 0·05) decreased and for creatine kinase, lactate dehydrogenase and IL-6 which increased significantly 1 h post-RE in both trials. There were no significant changes in other inflammatory and cardiovascular markers following both trials. A single injection of vitamin D3 improved insulin resistance and β-cell function following RE in previously vitamin D-deficient resistance-trained males. Conversely, the injection did not change muscle damage and the inflammatory response to acute RE. Intramuscular vitamin D replacement may have key implications for the promotion of glucose metabolism and lowering the risk of diabetes in vitamin D-deficient individuals.
机译：维生素D缺乏现在是影响多种生理功能的公认问题。本研究的目的是评估单剂量维生素D3注射对维生素D型耐缺乏症患者的抗性运动（RE）的炎症，肌肉损伤，代谢和心血管反应的影响。在两个单独的试验期间获得来自十四维生素D缺乏耐受培训的男性的血液样本：降低维生素D（LVD）和更高的维生素D（HVD，维生素D3注射后HVD）。在基线中，在基线中，在基线中进行代谢，炎症，肌肉损伤和心血管标记。对于胰岛素抵抗（HOMA-IR）的胰岛素和稳态模型评估存在显着的试验 - 逐时相互作用，与LVD试验相比，在HVD试验中，在HVD试验中显着（P <0·05），在HVD试验中下降了1小时。 HVD试验中β细胞功能（HOMA-β）β细胞功能（HOMA-β）的宿舍模型评估下降。对于血糖而言，显着（P <0·05）降低，对于肌酸激酶，乳酸脱氢酶和IL-6，两项试验后重新重新均显着增加，乳酸激酶和IL-6的血糖显着增加。两项试验后，其他炎症和心血管标志物没有显着变化。单一注射维生素D3改善胰岛素抗性和β细胞功能在预先维生素D缺乏耐受性培训的男性中。相反，注射不会改变肌肉损伤和对急性重新的炎症反应。肌内维生素D更换可能对促进葡萄糖代谢并降低维生素D缺陷个体的糖尿病风险的关键意义。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号