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首页> 外文期刊>The Canadian journal of hospital pharmacy. >Stability of Hydrocortisone, Nifedipine, and Nitroglycerine Compounded Preparations for the Treatment of Anorectal Conditions
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Stability of Hydrocortisone, Nifedipine, and Nitroglycerine Compounded Preparations for the Treatment of Anorectal Conditions

机译：氢化体，硝苯胺和硝基甘油的稳定性化制剂用于治疗肛肠条件

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INTRODUCTION: Anal fissure is a painful condition associated with hypertonia of the internal anal sphincter. Treatments are aimed at relaxing the internal sphincter, reducing pain, and increasing local blood flow, which stimulates fissure healing. Treatments include hydrocortisone, nitroglycerine, and calcium-channel blockers, such as nifedipine and diltiazem. The choice of base is an important consideration when compounding preparations. Nonaqueous bases such as petrolatum offer better adherence and longer residence time than creams. Furthermore, preparations are typically more stable in nonaqueous bases, because hydrolysis is less likely in the absence of water. For instance, the US Pharmacopeia recommends maximum beyond-use dates (BUDs) in the absence of stability information of not more than 6 months for nonaqueous formulations and not more than 30 days for water-containing topical formulations.
机译：介绍：肛裂是与内部肛门括约肌高渗的痛苦条件。 治疗旨在放松内部括约肌，减少疼痛，增加局部血流，刺激裂缝愈合。 治疗包括氢化氨酸，硝基甘油和钙通道阻滞剂，例如硝苯地平和尼堤扎姆。 基础的选择是复合制剂时的重要考虑因素。 凡士药等非水基础提供比乳膏更好的粘附和较长的停留时间。 此外，在非水基碱中通常更稳定制剂，因为水解在没有水的情况下不太可能。 例如，美国药典建议在没有超过6个月的非水式制剂的稳定性信息的情况下推荐最大的超越日期（芽），并且不超过30天的水局部制剂。

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