...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Canadian journal of hospital pharmacy. >Drug-Induced QT Interval Prolongation in Children: Are the Kids Alright?
【24h】

Drug-Induced QT Interval Prolongation in Children: Are the Kids Alright?

机译：药物诱导的Qt间隔儿童延长：孩子们好吗？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Torsades de pointes (TdP) is a polymorphic ventricular tachycardia associated with prolongation of the heart rate-corrected QT (QTc) interval on an electrocardiogram (ECG). TdP can be catastrophic, as it may result in sudden cardiac death.1 QTc interval prolongation may be inherited or acquired. The inherited form is represented by congenital long QT syndrome, of which there are at least 15 types, whereas the acquired form is most commonly caused by drugs. In the past 3 decades, several drugs, including astemizole, cisapride, grepafloxacin, prenylamine, and terfenadine, have been withdrawn from the Canadian market because of deaths due to TdP. Nonetheless, more than 100 drugs with the potential to prolong the QTc interval and cause TdP remain available. Although most clinicians are familiar with the potential for drug-induced QTc interval prolongation and TdP in adults, many are less aware that this adverse drug reaction can also occur in pediatric populations. However, many cases of drug-induced TdP in children have been published. Pediatric cases of TdP have been associated with various drugs, including astemizole, cisapride, pentamidine, risperidone, antiarrhythmic agents (amiodarone, procainamide, and sotalol), and antifungals (fluconazole and voriconazole).
机译：扭曲DE指向（TDP）是一种与心脏率校正的QT（QTC）间隔的延长相关的多晶型心室性心动过速，在心电图（ECG）上。 TDP可能是灾难性的，因为它可能导致心脏病突然死亡.1 QTC间隔延长可能是遗传或获得的。遗传形式由先天性长QT综合征表示，其中至少有15种类型，而获得的形式最常由药物引起。在过去的三十年中，几种药物，包括Astemizole，CisaPride，Grepafloxacin，戊胺和三丁胺，由于TDP因死亡而被取消了加拿大市场。尽管如此，超过100种具有延长QTC间隔的药物并导致TDP仍然可用。虽然大多数临床医生熟悉药物诱导的QTC间隔延长和成人TDP的潜力，但许多人不太意识到这种不利的药物反应也可能发生在儿科群体中。然而，许多药物诱导的儿童TDP病例已经发表。 TDP的儿科病例与各种药物有关，包括Astemizole，CisaPride，芬太丁，抗真菌酮，抗真瘤剂（胺碘酮，ProcabainaMide和Sottalol）和抗真菌（氟康唑和伏立康唑）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号