Amlodipine is a calcium-channel blocker often used to treat hypertension in adults and children. In Canada, amlodipine is available as tablets containing a quantity of amlodipine besylate (molar mass 567.05 g/mol) equivalent to 2.5 mg, 5 mg, or 10 mg of amlodipine base (molecular weight 408.87). Nahata and others5 reported the stability of compounded amlodipine besylate suspensions in 1999. The suspensions, containing the equivalent of 1 mg/mL of amlodipine base, were prepared from commercial tablets using either a 1:1 mixture of methylcellulose 1% and syrup or a 1:1 mixture of OraPlus and OraBlend vehicles (Perrigo, Dublin, Ireland). The authors concluded that both preparations were stable when stored in plastic prescription bottles for up to 91 days at 4°C and for up to 56 days at 25°C. The current study was undertaken to evaluate the stability of amlodipine besylate suspensions (equivalent to amlodipine base 1 mg/mL) in dye-free Oral Mix vehicle at 5°C and 25°C for up to 90 days.
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