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首页> 外文期刊>The Canadian journal of hospital pharmacy. >Duration of Antibiotic Therapy in Sepsis Secondary to Urinary Stones: A Retrospective Observational Study
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Duration of Antibiotic Therapy in Sepsis Secondary to Urinary Stones: A Retrospective Observational Study

机译：患有尿液中的抗生素治疗的持续时间，泌尿石：回顾性观测研究

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摘要

Pharmacists are essential members of antimicrobial stewardship programs, which have been in place for several years in many institutions, in response to the urgent threat posed by antibiotic resistance. It is well established that prolonged antibiotic exposure is associated with an increased risk of antimicrobial resistance, infection with Clostridioides difficile (previously known as Clostridium difficile), and adverse events; however, research to optimize the duration of antibiotic therapy is still needed for many infections. During weekly antimicrobial stewardship rounds at the authors' institution, it was noted that some patients presenting with an obstructive infected urinary stone were treated with a 2-week course of antibiotics, whereas others were treated with antibiotics until removal of the stone. Although guidelines recommend that removal of infected urinary stones not be undertaken until the infection has been adequately treated, the appropriate duration of antibiotic therapy has not been defined. To help address this gap in knowledge, we conducted a retrospective observational study to compare effectiveness and safety outcomes for patients admitted with sepsis secondary to one or more obstructive urinary stones, who were treated with the 2 most common durations of antibiotic therapy.
机译：药剂师是抗微生物管道方案的重要成员，该计划已经在许多机构中已经到达了几年，以应对抗生素抗性所带来的紧急威胁。很明显，延长的抗生素暴露与抗微生物抗性的风险增加有关，用梭菌氧化钛酸梭菌感染（以前称为梭菌梭菌）和不良事件;然而，对于许多感染仍需要优化抗生素治疗持续时间的研究。在当时的抗微生物管道在作者所机构中，有人指出，一些患有阻塞性感染的泌尿石的患者被治疗2周的抗生素疗程，而其他患者患有抗生素治疗，直至移除石头。虽然指导方针建议除去未进行感染的尿石，直到感染已被充分处理，尚未确定抗生素治疗的适当持续时间。为了帮助解决知识的这种差距，我们进行了回顾性的观察研究，以比较患者患有一次或多次阻塞性泌尿石的患者的患者的有效性和安全结果，他们用2个最常见的抗生素治疗患者治疗。

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