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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >P.082 Cannabinoids in the treatment of behavioural symptoms of autism: a rapid review to guide practice
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P.082 Cannabinoids in the treatment of behavioural symptoms of autism: a rapid review to guide practice

机译：P.082大麻素治疗自闭症的行为症状：快速审查指导实践

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摘要

Background: Legalization of recreational cannabis in Canada has increased the presence of cannabis in the public mind. There are online parent advocacy groups which are already calling for the use of cannabinoids in pediatric developmental and behavioural conditions such as Autism Spectrum Disorder (ASD). We set out to perform a rapid review of existing literature regarding use of cannabinoid products in the treatment of the behavioural domains of ASD. Methods: Key search terms were identified in collaboration with a medical librarian and combined into standardized search filters. A total of 55 articles were identified, of which only two included primary data regarding the use of cannabinoids to control behavioural symptoms of ASD in pediatric populations. Results: Both studies found significant reductions in the behavioural measures examined - which included inappropriate speech, irritability, stereotyped behaviours and self injurious behaviours - after treatment with Cannabinoids. Conclusions: The minimal existing evidence indicates the use of cannabinoid products may be useful in improving behavioural difficulties in children with ASD. However, there is a complete lack of well powered, rigorous studies. Further studies with larger cohorts are needed before any recommendations can be confidently made for or against the use of cannabinoids in this population.
机译：背景：加拿大在加拿大休闲大麻的合法化增加了大麻在公众脑海中的存在。有在线父母倡导团体已经呼吁在儿科发育和行为条件下使用大麻素，如自闭症谱系障碍（ASD）。我们首先对现有文献进行了快速审查，了解有关大麻素产品在治疗ASD的行为域中的使用。方法：通过与医疗图书管理员协作识别密钥搜索条件，并将其组合成标准化搜索过滤器。鉴定了总共55篇文章，其中只有两种包括大麻素使用大麻素来控制儿科群体的行为症状的主要数据。结果：两项研究都发现审查的行为措施的显着减少 - 其中包括不适当的演讲，烦躁，陈规定型的行为和自我伤害行为 - 在用大麻素治疗后进行治疗。结论：最小现有证据表明，使用大麻产品的使用可能有助于改善亚本儿童的行为困难。但是，有完全缺乏良好的动力，严格的研究。在任何建议可以自信地制造或针对这种人群中的大麻素使用的任何建议之前需要进行更大的群组的进一步研究。

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