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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Absence of age-related neurodegenerative changes during SIV infection and treatment in aged macaques
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Absence of age-related neurodegenerative changes during SIV infection and treatment in aged macaques

机译：在SIV感染和老年猕猴中治疗期间没有年龄相关的神经退行性变化

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摘要

The advent of combined antiretroviral therapy (CART) has changed HIV infection from a lethal disease to a chronic infection. CART has substantially mitigated infection-associated immunosuppression, related opportunistic infections and HIV encephalitis, nevertheless a substantial percentage of infected individuals are afflicted with a spectrum of HIV-associated neurological disorders (HAND). As approximately 45% of HIV-infected subjects in developed countries are over the age of 50, it has been hypothesized that infection may exacerbate age related neurodegenerative processes. We used the nonhuman primate SIV infection model to test whether chronic infection of aged primates, with or without CART, is associated with accelerated age-related neurodegeneration. Two dozen aged macaques (average age 18 years at entry 20 years at the end) were divided into two groups, half infected with SICmac251 and the other half not. After 10 months, half of each of these groups were either treated or not with CART and followed for an additional 6 months. We previously reported the clinical and neurobehavioural outcome. Here we compared the molecular and histologic findings in the four groups. Using a broad spectrum of histological markers, we found no evidence in the macaques of neuropathological changes associated with aging in humans. While the number of animals is small and length of infection limited, this study does not support the hypothesis that lentiviral infection or treatment accelerates age-related neurodegenerative changes in the primate brain.
机译：组合抗逆转录病毒治疗（购物车）的出现已经将艾滋病毒感染从致死的疾病转变为慢性感染。推车具有基本缓解的感染相关免疫抑制，相关的机会性感染和HIV脑炎，然而，受感染的个体的大量百分比受到艾滋病毒相关的神经系统障碍（手）的频谱。由于大约45％的发达国家的艾滋病毒感染受试者在50岁以上，已经假设感染可能会加剧年龄相关的神经退行过程。我们使用非人类灵长类会病毒性SIV感染模型来测试是否与或没有推车的慢性感染，有或没有推车，与加速的年龄相关的神经变性有关。两次老年的猕猴（在最终进入的20年的平均年龄）分为两组，一半感染了Sicmac251和另一半。 10个月后，这些组中的一半是用推车治疗或不需要额外的6个月。我们之前报道了临床和神经兽的结果。在这里，我们将四组中的分子和组织学结果进行了比较。使用广谱的组织学标志物，我们发现没有人类衰老相关的神经病理学变化的猕猴。虽然动物数量小而感染有限度，但该研究不支持慢病毒感染或治疗加速灵感脑中年龄相关神经变化的变化的假设。

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