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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >P.009 Characterizing drug-resistant epilepsy in an adult cohort with new-onset epilepsy
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P.009 Characterizing drug-resistant epilepsy in an adult cohort with new-onset epilepsy

机译：P.009在成人队列中表征耐药性癫痫，其中包含新的癫痫患者

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Background: There are few studies exploring rates of drug resistant epilepsy in populations with new-onset epilepsy (NOE). This prospective cohort study characterizes the development of drug-resistant epilepsy (DRE) and risk factors in an adult cohort with NOE or newly-diagnosed epilepsy (NDE). Methods: Patients are from the Single Seizure Clinic (SSC) in Saskatoon, SK between 2011 and 2018. The SSC sees patients who experience their first seizure; approximately 30% are diagnosed with epilepsy. Patients were followed prospectively. We identified the following variables in the cohort: epilepsy type, seizure onset, etiology, syndromes, and rates of DRE. Inclusion criteria included patients with NO and NDE, at least 18 years at diagnosis, and a minimum 1 year of follow-up. Results: Ninety-five patients were included, 46 females and 49 males. Median age of onset was 33 years. Of those, 28.4% developed DRE. Average time between onset and DRE diagnosis was 1.44 years. Bivariate analysis identified age, gender, and cranial trauma as significant risk factors for DRE. The multivariate model was not significant. Conclusions: Our study shows that patients with new-onset epilepsy have are less likely to develop DRE compared with patients from epilepsy clinics. This study contributes valuable information about NO epilepsy in adults and the development of DRE.
机译：背景：少数研究探索患有新发病癫痫（NOE）的毒性癫痫率的研究。这项前瞻性队列研究表征了耐药性癫痫（DRE）和危险因素的含有NOE或新诊断的癫痫（NDE）的危险因素。方法：患者来自Saskatoon，SK的单一癫痫诊所（SSC）2011年和2018年间。SSC看到经历他们的第一次癫痫发作的患者;大约30％被诊断出癫痫患者。患者潜在前瞻性。我们在队列中确定了以下变量：癫痫类型，癫痫发作，病因，综合征和DRE的速度。纳入标准包括患者，诊断至少18年，至少1年后续后续行动。结果：包括九十五名患者，46名女性和49名男性。起爆的中位年龄为33年。其中，28.4％开发了DRE。起始和DRE诊断的平均时间为1.44岁。生物分析确定年龄，性别和颅骨创伤，作为DRE的重要风险因素。多变量模型并不重要。结论：我们的研究表明，与来自癫痫诊所的患者相比，新发病癫痫的患者不太可能开发DRE。这项研究有助于在成人中没有癫痫的宝贵信息和DRE的发展。

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