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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Cerebrospinal Fluid Pleocytosis in Critical Care Patients With Seizures
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Cerebrospinal Fluid Pleocytosis in Critical Care Patients With Seizures

机译：脑脊液渗透癫痫发作患者患者

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Objectives: To assess the etiology of cerebrospinal fluid (CSF) pleocytosis in critical care patients with seizure(s) or status epilepticus (SE). Many previous studies, some performed decades ago, concluded that CSF pleocytosis may be entirely attributable to seizure activity. Methods: We undertook a retrospective chart review of adult patients with an admitting or acquired diagnosis of seizure(s) or SE in critical care units at the Winnipeg Health Sciences Centre between 2009 and 2012. Patients were identified through a critical care information database at a tertiary care center. We limited our study to patients who had lumbar punctures at our center within 5 days of seizure(s) or SE. Results: Of 426 patients with seizures in critical care units, 51 met the inclusion criteria. Seizure subtypes included focal seizures (5 or 10%), generalized seizures (14 or 27%), and SE (32 or 63%). Twelve (seven with SE) of the 51 (24%) were found to have CSF pleocytosis. A probable etiological cause for the CSF pleocytosis was identified in all 12 cases. Conclusions: We conclude that seizures do not directly induce a CSF pleocytosis. Instead, the CSF pleocytosis more likely reflects the underlying acute or chronic brain process responsible for the seizure(s). This was not readily apparent in early studies without magnetic resonance imaging (MRI) of the brain and currently available laboratory investigations. An etiological cause of CSF pleocytosis must always be sought when patients present with seizures and it should never be assumed that seizures are the cause.
机译：目的：评估脑脊液（CSF）患者在癫痫发作患者的脑脊液（CSF）膜肿瘤病的病因或癫痫患者（SE）（SE）。在几十年前的几十年前，许多先前的研究得出结论认为，CSF滋润增多症可能完全归因于癫痫发作活动。方法：我们对2009年至2012年之间的Winnipeg卫生科学中心的严重护理单位进行了录取或获得的癫痫发作单位的认可或获得的诊断，对成人患者进行了回顾性图表审查。第三级护理中心。我们将我们的研究限制在癫痫发作后5天内在我们的中心患者腰部穿孔的患者。结果：关键保健单位缉获患者426例，51符合纳入标准。癫痫发作亚型包括焦癫痫发作（5或10％），广义癫痫发作（14或27％）和SE（32或63％）。发现了51（24％）的十二（70％）具有CSF膜瘤病。在所有12例中鉴定了CSF脂肪肾病症的可能的病因因子。结论：我们得出结论，癫痫发作不会直接诱导CSF脂肪抑血病。相反，CSF型脂肪炎更可能反映负责癫痫发作的潜在急性或慢性脑过程。在没有磁共振成像（MRI）的早期研究中，这在大脑和目前可用的实验室调查中并不明显。当患者存在癫痫发作时，必须始终寻求CSF脂肪尿量的病因生理原因，并且永远不应该假设癫痫发作是原因。

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