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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Review of the Diagnostic Challenges of Lambert-Eaton Syndrome Revealed Through Three Case Reports
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Review of the Diagnostic Challenges of Lambert-Eaton Syndrome Revealed Through Three Case Reports

机译：通过三个案例报告审查Lambert-eaton综合征的诊断挑战

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摘要

Lambert-Eaton syndrome (LES) is a rare immune-mediated disorder characterized by proximal leg weakness, autonomic symptoms and hypoactive tendon reflexes. The paraneoplastic form is associated with small-cell lung cancer in 50-60% of cases, whereas the remaining cases are found in younger adults with a higher likelihood of coexisting autoimmune disease. The early recognition of LES is crucial for improving clinical outcomes but remains a major challenge. In this review, we analyze the clinical characteristics and diagnostic considerations in treating LES through a series of three case studies, one of which showed definitive response to pyridostigmine and corticosteroid combination therapy, followed by spontaneous remission. Patients were assessed by image-based screening, serological testing and electrophysiological evaluations, which included respiratory and autonomic testing. A better understanding of the common pitfalls in the clinical, serological and neurophysiologic diagnosis of LES through assessment of typical LES dysfunction throughout the nervous system should enable improved recognition and treatment of this syndrome.
机译：Lambert-eaton综合征（LES）是一种罕见的免疫介导的疾病，其特征在于近端腿部弱点，自主症状和低温肌腱反射。榫胞膜形式在50-60％的病例中与小细胞肺癌有关，而剩余的病例是在年轻的成年人中发现的，具有更高的自身免疫性疾病的可能性。 LES的早期识别对于改善临床结果来说至关重要，但仍然是一个重大挑战。在本综述中，我们通过一系列三种案例研究分析治疗LES的临床特征和诊断考虑，其中一个案例研究显示对吡吡替米胺和皮质类固醇组合治疗的最终反应，其次是自发缓解。通过基于图像的筛选，血清学检测和电生理学评估评估患者，包括呼吸和自主检测。通过评估在整个神经系统中，通过评估典型的LES功能障碍的临床，血清学和神经生理诊断中的常见缺陷应该能够改善这种综合征的识别和治疗。

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