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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Pituitary Adenoma Associated With Rathke’s Cleft Cyst: Report of 15 Cases
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Pituitary Adenoma Associated With Rathke’s Cleft Cyst: Report of 15 Cases

机译：与Rathke的裂缝囊肿有关的垂体腺瘤：15例报告

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Objective: The concomitant presence of pituitary adenoma (PA) with Rathke’s cleft cyst (RCC) is rare, and most of the literature published is case reports. RCC’s clinicopathological features have not been well described. Methods: We retrospectively reviewed the data of 15 patients with PA associated with RCC. We also provide a systematic review of the literature. Results: The patients included males and seven females. The transsphenoidal approach was adopted for all patients except one, who underwent right frontal craniotomy. Complete resection was achieved in nine cases, with grossly complete resection in five and partial removal in one. Of the PA subtypes available, five patients had nonfunctional pituitary adenomas, three had multiple-hormone secreting PAs, three had prolactin-producing adenomas, and one had a growth hormone-secreting adenoma. All of the patients’ symptoms and abnormal endocrine test results resolved or were relieved after surgery. The mean follow-up time was 27.6±16.6 months. All of the patients recovered well and had no signs of recurrence during their follow-up, except for one patient. Conclusions: A cyst-like signal indicated on images or cystic materials encountered during operation in a patient with PA suggest the possibility of PA associated with RCC. Transsphenoidal surgery is the preferred approach and can resolve or relieve patients’ symptoms to a great extent. Histologically, nonfunctional PA and prolactinoma are the most common types of PA coexisting with RCC; the mechanisms of PA associated with RCC need to be investigated further.
机译：目的：伴随垂体腺瘤（PA）与Rathke的裂缝（RCC）的存在是罕见的，并且大多数文献出版的是案例报告。 RCC的临床病理特征尚未熟悉。方法：我们回顾性地审查了15例与RCC相关的PA患者的数据。我们还提供对文献的系统审查。结果：患者包括男性和七个女性。除了一个患者的患者采用了经胸腔的方法，曾接受过右前轮颅骨。完全切除在九种情况下实现，在五个和部分删除中含有严重完全切除。在可用的PA亚型中，五名患者具有非功能性垂体腺瘤，三个有多个激素分泌PAS，三种患有催乳素的腺瘤，一种腺瘤分泌腺瘤的腺瘤。所有患者的症状和异常内分泌测试结果都解决或术后释放。平均随访时间为27.6±16.6个月。除了一个患者外，所有患者均未恢复良好，在后续行动中没有复发迹象。结论：在患有PA患者的患者中遇到的图像或囊性材料上指示的囊肿状信号表明PA与RCC相关的可能性。双耳形状手术是优选的方法，可以在很大程度上解决或缓解患者的症状。组织学上，非功能性Pa和催乳素瘤是与RCC共存的最常见类型的PA共存;需要进一步调查与RCC相关的PA机制。

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