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首页> 外文期刊>The Canadian Journal of Neurological Sciences: le Journal Canadien des Sciences Neurologiques >Anxiety and Depression in Adult First Seizure Presentations
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Anxiety and Depression in Adult First Seizure Presentations

机译：成人首次扣押演示文稿中的焦虑和抑郁症

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Objective: To define the prevalence of psychiatric symptoms of anxiety and depression in patients at the time of their first seizure presentation to a neurologist. Methods: Our pilot study uses a cohort approach with multimodal data (clinical, social, structural [3T magnetic resonance imaging], and functional [electroencephalogram]). We screened 105 patients referred to the Halifax First Seizure Clinic between 2014 and 2016 and 51 controls. All participants completed two screening questionnaires: Neurological Disorders Depression Inventory for Epilepsy and Generalized Anxiety Disorder 7-Item. After applying the exclusion criteria, the study population consisted of 57 patients with unprovoked first seizure and 31 controls. The prevalence of anxiety and depression was based on cutoff scores of >15 and >14 respectively. Results: Unprovoked first seizure patients showed higher prevalence of depression (33%) compared with control (6%) with an odds ratio (OR) of 2.75 (95% confidence interval [CI], 0.72-10.5). There was no significant difference in the prevalence of anxiety between control subjects (9.7%) and unprovoked first seizure patients (23%). Subcategory analysis conducted after diagnosis confirmation revealed significantly increased OR of depression in patients diagnosed with new-onset epilepsy (OR, 11.6; 95% CI, 2.1-64.0) and newly diagnosed epilepsy (OR, 20.0; 95% CI,2.2-181), but not first seizure only patients (OR, 2.2; 95% CI,0.28-17.6) compared with control. Conclusions: Our study supports a bidirectional relationship between the first seizure and depression. Prevalence rate of depression increased with duration of undiagnosed epilepsy at the time of first clinical assessment.
机译：目的：定义首次癫痫发作给神经病学家时患者焦虑症状和抑郁症的患病率。方法：我们的试验研究采用了群组方法（临床，社会，结构[3T磁共振成像]和功能[脑电图]）。我们在2014年至2016年间，我们筛选了105名患者提到哈利法克斯第一癫痫诊所和51例对照。所有参与者完成了两次筛查问卷：癫痫和广义焦虑症7项的神经系统疾病抑郁症库存。在申请排除标准后，研究人群由57名未兴奋的癫痫发作和31例对照组成。焦虑和抑郁症的患病率分别基于> 15和> 14的截止分数。结果：未加工的首次癫痫发作患者表现出较高的抑郁症（33％）与对照（6％）相比，含量比（或）为2.75（95％置信区间[CI]，0.72-10.5）。对照对象（9.7％）和未加工的首次癫痫发作患者（23％）没有显着差异。在诊断确认后进行的亚类别分析显示，患有新发病癫痫患者（或11.6; 95％CI，2.1-64.0）和新诊断的癫痫（或20.0; 95％CI，2.2-181），显着增加或抑郁症，但第一次仅癫痫发作（或2.2; 95％CI，0.28-17.6）与对照相比。结论：我们的研究支持第一次癫痫发作和抑郁症之间的双向关系。在首次临床评估时，抑郁症的患病率增加了未诊断的癫痫患者。

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