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Epilepsy, Physical Activity and Sports: A Narrative Review

机译:癫痫,身体活动和运动:叙述审查

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摘要

People with epilepsy (PWE) are less physically active compared with the general population. Explanations include prejudice, overprotection, unawareness, stigma, fear of seizure induction and lack of knowledge of health professionals. At present, there is no consensus on the role of exercise in epilepsy. This paper reviews the current evidence surrounding the risks and benefits associated with physical activity (PA) in this group of patients. In the last decade, several publications indicate significant benefits in physiological and psychological health parameters, including mood and cognition, physical conditioning, social interaction, quality of life, as well as potential prevention of seizure presentation. Moreover, experimental studies suggest that PA provides mechanisms of neuronal protection, related to biochemical and structural changes including release of β-endorphins and steroids, which may exert an inhibitory effect on the occurrence of abnormal electrical activity. Epileptic discharges can decrease or disappear during exercise, which may translate into reduced seizure recurrence. In some patients, exercise may precipitate seizures. Available evidence suggests that PA should be encouraged in PWE in order to promote wellbeing and quality of life. There is a need for prospective randomized controlled studies that provide stronger clinical evidence before definitive recommendations can be made.
机译:与一般人群相比,癫痫患有癫痫(PWE)的人不太积极活跃。解释包括偏见,过度保护,无意,耻辱,对癫痫发作的恐惧和对健康专业人士的知识。目前,对癫痫患者的作用没有达成共识。本文审查了本群患者中与体育活动(PA)相关的风险和益处的现行证据。在过去的十年中,一些出版物表明了生理和心理健康参数的显着效果,包括情绪和认知,身体调节,社会互动,生活质量以及潜在预防扣押介绍。此外,实验研究表明,PA提供神经元保护机制,与生物化学和结构变化有关,包括释放β-内啡肽和类固醇,这可能对发生异常电活动的发生施加抑制作用。癫痫发出可以在运动期间减少或消失,这可能转化为降低的癫痫发作复发。在一些患者中,运动可能会促使癫痫发作。可用证据表明,应在PWE中鼓励PA,以促进福利和生活质量。需要进行预期随机对照研究,以便在明确的建议之前提供更强的临床证据。

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