...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The international journal of developmental biology >Regulatory heterochronies and loose temporal scaling between sea star and sea urchin regulatory circuits
【24h】

Regulatory heterochronies and loose temporal scaling between sea star and sea urchin regulatory circuits

机译：海星和海胆监管电路之间的监管异旋和宽松的时间缩放

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

It has long been argued that heterochrony, a change in relative timing of a developmental process, is a major source of evolutionary innovation. Heterochronic changes of regulatory gene activation could be the underlying molecular mechanism driving heterochronic changes through evolution. Here, we compare the temporal expression profiles of key regulatory circuits between sea urchin and sea star, representative of two classes of Echinoderms that shared a common ancestor about 500 million years ago. The morphologies of the sea urchin and sea star embryos are largely comparable, yet, differences in certain mesodermal cell types and ectodermal patterning result in distinct larval body plans. We generated high resolution temporal profiles of 17 mesodermally- ,endodermally- and ectodermally-expressed regulatory genes in the sea star, Patiria miniata, and compared these to their orthologs in the Mediterranean sea urchin, Paracentrotus lividus. We found that the maternal to zygotic transition is delayed in the sea star compared to the sea urchin, in agreement with the longer cleavage stage in the sea star. Interestingly, the order of gene activation shows the highest variation in the relatively diverged mesodermal circuit, while the correlations of expression dynamics are the highest in the strongly conserved endodermal circuit. We detected loose scaling of the developmental rates of these species and observed interspecies heterochronies within all studied regulatory circuits. Thus, after 500 million years of parallel evolution, mild heterochronies between the species are frequently observed and the tight temporal scaling observed for closely related species no longer holds.
机译：它已经长期被认为，异形成像是发展过程的相对时间的变化，是进化创新的主要来源。调节基因活化的异调变化可以是通过进化驱动异形变化的底层分子机制。在这里，我们比较海胆和海星之间的关键监管电路的时间表达轮廓，代表两类棘鱼胚层，分享了大约5亿年前共同的祖先。海胆和海星胚胎的形态在很大程度上是可比的，但某些中胚层细胞类型的差异和异常图案化导致不同的幼虫体系。我们在海星，Patiria Miniata中产生了高分辨率的17个缺口，内胚层和周边和异位和异位和异位和异位和异位和异位和异常的表达的调节基因，并将这些与其在地中海海胆，ParacoreRotus Lividus中的地区的矫形器相比。我们发现，与海胆相比，母亲与Zygotic过渡的延迟，同意海核，同意海星中的较长裂解阶段。有趣的是，基因激活的顺序显示了相对分散的中胚层电路的最高变化，而表达动态的相关性在强保守的内胚层电路中是最高的。我们检测到这些物种的发育速率的松散缩放，并观察到所有研究的监管电路中的interpecies异旋奖。因此，经过5亿多年的平行进化，经常观察到物种之间的温和异旋体，并且对密切相关的物种观察到的紧密颞缩放不再持有。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号