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首页> 外文期刊>The journal of alternative and complementary medicine: research on paradigm, practice, and policy >Effects of Saffron on Cognition, Anxiety, and Depression in Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Double-Blind Placebo-Controlled Trial
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Effects of Saffron on Cognition, Anxiety, and Depression in Patients Undergoing Coronary Artery Bypass Grafting: A Randomized Double-Blind Placebo-Controlled Trial

机译：藏红花对冠状动脉旁路嫁接患者认知，焦虑和抑郁症的影响：随机双盲安慰剂对照试验

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Objectives: Cognitive decline, depression, and anxiety are among the major concerns in patients undergoing coronary artery bypass grafting (CABG). Crocus sativus L. (saffron) seems to be a promising candidate for treatment of these conditions. Design: In this 12-week, randomized, double-blind, placebo-controlled clinical trial, men and women with on-pump CABG, who had Wechsler Memory Scale (WMS) score 70 and age 70 years, received either saffron capsules (15mg/twice daily) or placebo. Patients were excluded if they had history of treatment with saffron or acetylcholinesterase inhibitors, comorbid neuropsychiatric disorders, serious medical conditions other than cardiovascular diseases, and hypersensitivity to herbal compounds. The primary outcome was defined as the difference in mean total score changes for WMS-Revised from the baseline to week 12 between the saffron and placebo groups. Secondary outcomes included difference in mean score changes from baseline to endpoint between the two treatment groups for Mini Mental Status Examination and subscales of Hospital Anxiety and Depression Scale (www.irct.ir; IRCT201408071556N63). Results: No significant difference was detected in primary or secondary outcomes between the saffron and placebo groups. Also, no significant timextreatment interaction effect was found for any of the scales. Conclusions: The results of this trial do not support the hypothesis of potential benefits of saffron in treatment of CABG-related neuropsychiatric conditions.
机译：目的：认知衰退，抑郁和焦虑是冠状动脉旁路接枝（CABG）患者的主要问题。 Crocus Sativus L.（番红花）似乎是治疗这些条件的有希望的候选者。设计：在这个12周，随机，双盲，安慰剂控制的临床试验，男女搭载泵车的型号，人员记忆量表（WMS）得分＆ 70年代甚至70年来，收到番红花胶囊（每日15mg /两次）或安慰剂。如果患者患有藏红花或乙酰胆碱酯酶抑制剂的历史，可被含有甘油克或乙酰胆碱酯酶抑制剂，可染色体疾病以外的严重医疗病症，以及对草药化合物的超敏反应。主要结果被定义为从基线到藏红花和安慰剂组之间的基线修订的平均总分变化的差异。二次结果包括在迷你精神状态检查和医院焦虑和抑郁尺度的两种治疗组之间的基线与终点之间的平均分数变化的差异（www.irct.ir; irct201408071556n63）。结果：在藏红花和安慰剂组之间的初级或二次结果中没有检测到显着差异。此外，没有发现任何尺度的显着的计时相互作用效果。结论：该试验的结果不支持藏红花潜在益处的假设，治疗CABG相关的神经精神病症。

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