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Management of Menopause Symptoms with Acupuncture: An Umbrella Systematic Review and Meta-Analysis

机译:穴位患有针灸症状的管理:伞系统评论和荟萃分析

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Objectives: Vasomotor symptoms (VMSs) are the most common symptoms reported during menopause. Although hormone therapy is effective for reducing VMSs, its use is restricted in some women. Many women with VMSs thus seek nonhormonal, nonpharmacologic treatment options such as acupuncture. Design: An umbrella systematic review (SR) was conducted, supplemented by a search of published randomized controlled trials (RCTs), that assessed the effectiveness of acupuncture for VMSs, health-related quality of life (HRQOL), and adverse effects of treatment in perimenopausal or postmenopausal women. Meta-analyses were conducted using a random-effects model when data were sufficient. Results: Three SRs and four new RCTs were identified that met eligibility criteria. Meta-analyses of this study revealed statistically significant standardized mean differences (SMDs) associated with acupuncture compared with no acupuncture at reducing VMS frequency (SMD -0.66, 95% confidence interval [CI] -1.06 to -0.26, I-2=61.7%, 5 trials) and VMS severity (SMD -0.49, 95% CI -0.85 to -0.13, I-2=18.1%, 4 trials) and improving HRQOL outcomes (SMD -0.93, 95% CI -1.20 to -0.67, I-2=0.0%, 3 trials). SMDs were smaller or not statistically significant when acupuncture was compared with sham acupuncture. Conclusions: Evidence from RCTs supports the use of acupuncture as an adjunctive or stand-alone treatment for reducing VMSs and improving HRQOL outcomes, with the caveat that observed clinical benefit associated with acupuncture may be due, in part, or in whole to nonspecific effects. The safety of acupuncture in the treatment of VMSs has not been rigorously examined, but there is no clear signal for a significant potential for harm.
机译:目的:血管运动症状(VMS)是更年期报告的最常见的症状。虽然激素治疗对减少VMS有效,但其使用受到一些女性的限制。因此,许多患有VMS的女性寻求非同性恋,非武装治疗选择,如针灸。设计:进行了伞系统评价(SR),通过搜索已发表的随机对照试验(RCT),评估针灸对VMS的有效性,与卫生学寿命(HRQOL),以及治疗的不利影响围整天植物或绝经后妇女。当数据足够时,使用随机效应模型进行META分析。结果:确定了三个SRS和四个新的RCT,达到了资格标准。本研究的荟萃分析揭示了与针灸相关的统计学显着的标准化平均差异(SMDS),而没有针灸减少VMS频率(SMD -0.66,95%置信区间[CI] -1.06至-0.26,I-2 = 61.7% ,5项试验)和VMS严重程度(SMD -0.49,95%CI -0.85至-0.13,I-2 = 18.1%,4项试验)和改善HRQOL结果(SMD -0.93,95%CI -1.20至-0.67,i -2 = 0.0%,试验)。当针刺与假针刺相比,SMD较小或没有统计学意义。结论来自RCT的证据支持使用针灸作为减少VMS和改善HRQOL结果的辅助或独立治疗,该警告观察到与针灸相关的临床益处可能部分或全部到非特异性效应。针灸治疗VMS的安全性尚未严格检查,但没有明显的危害潜力。

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