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首页> 外文期刊>Protoplasma: An International Journal of Cell Biology >Physiology, phylogeny, early evolution, and GAPDH
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Physiology, phylogeny, early evolution, and GAPDH

机译:生理学,系统发育,早期进化和GAPDH

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摘要

The chloroplast and cytosol of plant cells harbor a number of parallel biochemical reactions germane to the Calvin cycle and glycolysis, respectively. These reactions are catalyzed by nuclear encoded, compartment-specific isoenzymes that differ in their physiochemical properties. The chloroplast cytosol isoenzymes of D-glyceraldehyde-3-phosphate dehydrogenase (GAPDH) harbor evidence of major events in the history of life: the origin of the first genes, the bacterial-archaeal split, the origin of eukaryotes, the evolution of protein compartmentation during eukaryote evolution, the origin of plastids, and the secondary endosymbiosis among the algae with complex plastids. The reaction mechanism of GAPDH entails phosphorolysis of a thioester to yield an energy-rich acyl phosphate bond, a chemistry that points to primitive pathways of energy conservation that existed even before the origin of the first free-living cells. Here, we recount the main insights that chloroplast and cytosolic GAPDH provided into endosymbiosis and physiological evolution.
机译:植物细胞的叶绿体和细胞溶胶分别含有许多并联生化反应锗,分别对钙林循环和糖溶解。这些反应被核编码,孤隔离的同工酶催化,其在其生理化学性质中不同。 D-甘油醛-3-磷酸脱氢酶(GAPDH)叶片胞质胞嘧啶脱氢酶(GAPDH)遗迹的历史历史:第一个基因的起源,细菌 - 古代分裂,真核生物的起源,蛋白质隔室的演变在真核生物进化期间,具有复合体积的藻类产物的起源和藻类中的次生胚胎。 GAPDH的反应机理需要硫酯的磷光解,以产生富含能量的酰基磷酸键,一种化学,即甚至在第一个自由活细胞的起源前也存在的节能途径。在这里,我们叙述了将叶绿体和细胞溶质GAPDH提供给内联的主要见解和生理进化。

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