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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Antibiofilm activities of ceragenins and antimicrobial peptides against fungal-bacterial mono and multispecies biofilms
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Antibiofilm activities of ceragenins and antimicrobial peptides against fungal-bacterial mono and multispecies biofilms

机译：Ceragenins和抗菌肽对真菌细菌单声道和多层生物膜的抗菌肽的抗生素

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摘要

Multispecies biofilms, in which both fungus and bacteria species can be present, play a significant role in persistent infections, and new therapeutic options are needed against them. In this study, the activities of ceragenins and antimicrobial peptides (AMPs) (magainin, cecropin A, LL-37) were investigated against multispecies biofilms formed by Candida albicans and four clinically important Gram-negative bacteria, including Pseudomonas aeruginosa, Acinetobacter baumannii, Escherichia coli, and Klebsiella pneumoniae. Our results show that CSA-13 and CSA-90 were the most effective agents against both mono and multispecies biofilms (P < 0.05). CSA-131 and CSA-192 showed the least antimicrobial activity against mono and fungal-bacterial multispecies biofilms. Inhibition of multispecies biofilms with CSA-13 and CSA-90 was also confirmed through fluorescence microscopy images. When AMPs evaluated alone, they proved ineffective against both C. albicans and Gram-negative bacteria at the concentrations tested. In these studies, ceragenins were much more effective than AMPs against multi or monospecies biofilms, especially those containing C. albicans.
机译：多层生物膜，其中真菌和细菌种类可以存在，在持续的感染中发挥重要作用，并对他们来说需要新的治疗选择。在这项研究中，研究了Cantida albicans和四个临床重要的革兰氏阴性细菌，包括假单胞菌铜绿假单胞菌，百年敏肽，鲍曼省，百年南省，百年敏（AcineTobia Coli和Klebsiella肺炎。我们的研究结果表明，CSA-13和CSA-90是对单声道和多层生物膜的最有效的药剂（P <0.05）。 CSA-131和CSA-192表现出对单一和真菌细菌多层生物膜的最少的抗微生物活性。还通过荧光显微镜图像证实了具有CSA-13和CSA-90的多层生物膜的抑制。当AMPS单独评估时，他们在测试的浓度下对C.醛糖和革兰氏阴性细菌进行了无效。在这些研究中，Ceragenins比AMPS对抗多或单体生物膜，特别是含有C. albicans的那些。

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