New pestallic acids and diphenylketone derivatives from the marine alga-derived endophytic fungus Pestalotiopsis neglecta SCSIO41403

Wang Jianjiao; Peng Qingyun; Yao Xingang; Liu Yonghong; Zhou Xuefeng

首页> 外文期刊>The Journal of Antibiotics: An International Journal >New pestallic acids and diphenylketone derivatives from the marine alga-derived endophytic fungus Pestalotiopsis neglecta SCSIO41403

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New pestallic acids and diphenylketone derivatives from the marine alga-derived endophytic fungus Pestalotiopsis neglecta SCSIO41403

机译：来自海藻藻藻藻藻生藻藻藻植物的新岩浆酸和二苯基酮衍生物缺乏疏忽SCSIO41403

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Three new carboxylic acid derivatives, pestallic acids F and G (1 and 2), pestalotiopyrone N (3), and a new diphenylketone derivative named neopestalone (5) were obtained from the liquid cultures of marine alga-derived endophytic fungus Pestalotiopsis neglecta SCSIO41403, along with six known compounds (4, 6-10). The structures of those new compounds were elucidated mainly by analysis of their NMR and MS data. The isolated compounds were evaluated for their anti-Dengue virus and COX-2 inhibitory activities, and two diphenylketone derivatives (5 and 6) exhibited obvious COX-2 inhibitory activities, with the IC50 values being 5.8 and 3.4 mu M, respectively.

机译：三种新的羧酸衍生物，岩丙酮葡萄球菌N（3）和新的二苯基酮衍生物命名为Neopestalone（5）的新的二苯基酮衍生物，得到了普通藻类灭绝的内生真菌植物的液体培养物疏忽SCSIO41403，与六种已知的化合物（4,6-10）一起。这些新化合物的结构主要通过分析其NMR和MS数据来阐明。评价分离的化合物的抗登革病毒和COX-2抑制活性，并且两种二苯基酮衍生物（5和6）表现出明显的COX-2抑制活性，IC 50值分别为5.8和3.4μm。

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《The Journal of Antibiotics: An International Journal》 |2020年第8期|共4页
作者
Wang Jianjiao; Peng Qingyun; Yao Xingang; Liu Yonghong; Zhou Xuefeng;
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作者单位

Chinese Acad Sci CAS Key Lab Trop Marine Bioresources &

Ecol Guangdong Key Lab Marine Mat Med;

Chinese Acad Sci CAS Key Lab Trop Marine Bioresources &

Ecol Guangdong Key Lab Marine Mat Med;

Southern Med Univ Guangzhou Key Lab Drug Res Emerging Virus Prevent Guangdong Prov Key Lab New;

Chinese Acad Sci CAS Key Lab Trop Marine Bioresources &

Ecol Guangdong Key Lab Marine Mat Med;

Chinese Acad Sci CAS Key Lab Trop Marine Bioresources &

Ecol Guangdong Key Lab Marine Mat Med;

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原文格式 PDF
正文语种 eng
中图分类药学;
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1. New pestallic acids and diphenylketone derivatives from the marine alga-derived endophytic fungus Pestalotiopsis neglecta SCSIO41403 [J] . Wang Jianjiao, Peng Qingyun, Yao Xingang, The Journal of Antibiotics: An International Journal . 2020,第8期

机译：来自海藻藻藻藻藻生藻藻藻植物的新岩浆酸和二苯基酮衍生物缺乏疏忽SCSIO41403
2. Pestalopyrones A-D, four tricyclic pyrone derivatives from the endophytic fungus Pestalotiopsis neglecta S3 [J] . Feng Li, Han Jing, Wang Jia, Phytochemistry . 2020,第1期

机译：PELEALOPYRONES A-D，来自内生真菌植物的四个三环催化剂衍生物疏忽S3
3. Varioloid A, a new indolyl-6,10b-dihydro-5aH-[1]benzofuro[2,3-b]indole derivative from the marine alga-derived endophytic fungus Paecilomyces variotii EN-291 [J] . Peng Zhang, Xiao-Ming Li, Xin-Xin Mao, Beilstein journal of organic chemistry. . 2016,第1期

机译：Varioloid A，一种新的吲哚基-6,10b-二氢-5aH- [1]苯并呋喃[2,3-b]吲哚衍生物，来自海洋藻类内生真菌变异拟青霉EN-291
4. Effect of salinity medium on antioxidant and antidiabetic activity marine endophytic fungus of asperegillus elegans ptf 9 [C] . Hani Mulyani, Nina Artanti, Irni Fitria, International Symposium on Applied Chemistry . 2017

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5. Insecticidal Activities of Chloramphenicol Derivatives Isolated from a Marine Alga-Derived Endophytic Fungus Acremonium vitellinum against the Cotton Bollworm Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae) [O] . Dan Chen, Peng Zhang, Tong Liu, 2018

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6. Insecticidal Activities of Chloramphenicol Derivatives Isolated from a Marine Alga-Derived Endophytic Fungus, Acremonium vitellinum, against the Cotton Bollworm, Helicoverpa armigera (Hübner) (Lepidoptera: Noctuidae) [O] . Dan Chen, Peng Zhang, Tong Liu, 2018

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New pestallic acids and diphenylketone derivatives from the marine alga-derived endophytic fungus Pestalotiopsis neglecta SCSIO41403

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