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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Emergence and spread of resistant N-meningitidis implicated in invasive meningococcal diseases during the past decade (2008-2017)
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Emergence and spread of resistant N-meningitidis implicated in invasive meningococcal diseases during the past decade (2008-2017)

机译：抗性N-脑膜炎的出现和传播涉及过去十年中侵袭性脑膜炎疾病（2008-2017）

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摘要

Neisseria meningitidis is one of the most crucial causes of bacterial meningitis worldwide. The incidence of meningitis due to N. meningitidis greatly changes from one geographical area to the other: 500,000-1,200,000 invasive meningococcal diseases occur each year, with 50,000-135,000 deaths. Once the diagnosis of bacterial meningitis is made, parenteral antibiotic treatment is started as soon as possible. A preventive treatment can also be proposed for those subjects at risk of exposure. Globally, resistance to antibiotics used in the treatment of prophylaxis of meningococcal disease is relatively rare. Penicillin is becoming less useful in the treatment of invasive meningococcal diseases because meningococcal isolates are increasingly less susceptible to this antibiotic. Meningococcal strains less susceptible to ceftriaxone or ciprofloxacin are rare. In addition, resistance to rifampicin is not a current concern as resistant isolates are rarely reported. In conclusion, the emergence of new meningococcal strains with decreasing susceptibility during the last decade should not be ignored, as this could be a worrying phenomenon in the future and justifies a judicious epidemiological survey on a continuous basis.
机译：Neisseria Meningitidis是全球细菌性脑膜炎最重要的原因之一。由于N. Meningitidis引起的脑膜炎发病率从一个地理区域到另一个地理区域大大变化：每年500,000-1200,000次侵入性脑膜炎疾病疾病，死亡50,000-135,000人。一旦制备了细菌脑膜炎的诊断，尽快开始肠外抗生素治疗。还可以为有暴露风险的受试者提出预防性处理。在全球范围内，用于治疗预防脑膜炎疾病的抗生素的抗性相对罕见。青霉素在治疗侵袭性脑膜炎球菌疾病时变得越来越缺乏，因为脑膜炎球菌分离物越来越易于​​这种抗生素。脑膜炎球菌菌株易受头孢菌或环丙沙星的抑菌稀有。此外，对利福平的抗性不是当前关注的是，因为很少报道抗性分离物。总之，在过去十年中，新脑膜炎球菌菌株的出现不应忽视，因为这可能是未来的令人担忧的现象，并以不断的方式证明了一个明智的流行病学调查。

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