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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Paradoxical growth effect of caspofungin on Candida spp. sessile cells not only at high drug concentrations
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Paradoxical growth effect of caspofungin on Candida spp. sessile cells not only at high drug concentrations

机译：Caspofungin对Candida SPP的矛盾生长效应。 无柄细胞不仅高于药物浓度

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摘要

According to the available literature, echinocandins display high anti-Candida spp. activity. Paradoxical growth (PG) of Candida spp. planktonic cells promoted by echinocandins is widely reported. Here we report on the ability of Candida spp. sessile cells to display PG when they are exposed to caspofungin in vitro, even at relatively low drug concentrations. Clinical significance of PG during echinocandin therapy of candidiasis remains uncertain. We assessed in vitro susceptibilities of Candida spp. sessile cells to caspofungin and analyzed the frequency of PG. The minimum inhibitory concentrations of caspofungin for sessile cells (SMICs) were determined for 70 clinical Candida spp. isolates (29 Candida albicans, 26 Candida parapsilosis, and 15 Candida glabrata isolates) and were defined as the lowest drug concentrations that resulted in at least 50% reduction in metabolic activity. PG was defined as a resurgence of growth (50% of that in the drug-free growth control well) at drug concentrations above the MIC. The caspofungin SMICs ranged from = 0.015 to 256 mu g ml(-1). We observed PG in 26.9-93.1% of isolates tested, depending on the Candida species and age of sessile cells. Antibiofilm activity of caspofungin is species-specific, and strongly strain-depending among C. albicans and C. parapsilosis isolates. Interestingly, PG was present also at relatively low caspofungin concentrations.
机译：根据可用的文献，Echinocandins显示出高抗念珠菌SPP。活动。矛盾的生长（pg）念珠菌spp。众所周知，通过海螺蛋白促进的浮游细胞。在这里，我们报告了Candida SPP的能力。即使在相对低的药物浓度下，当在体外暴露于Caspofungin时，术式细胞即使在相对较低的药物浓度下也会显示PG。 PG在念珠菌病期间PG的临床意义仍然不确定。我们评估了Candida SPP的体外敏感性。术术细胞到Caspofungin并分析PG的频率。测定了70个临床念珠菌SPP测定了术治疗细胞的最小抑制浓度（SMICS）。分离株（29例念珠菌，26名念珠菌甲状腺素和15名念珠菌菌类药物），并被定义为最低的药物浓度，导致代谢活性降低至少50％。 PG被定义为MIC的药物浓度的药物浓度的生长（＆ 50％在无药物生长控制孔中的50％）。 Caspofungin Smics的范围从＆ = 0.015至＆ 256 mu g ml（-1）。我们观察到在26.9-93.1％的分离株中观察到的pg，这取决于念珠菌细胞的念珠菌物种和年龄。 Caspofungin的抗生素活性是物种特异性，并且强大的菌株，取决于C. albicans和C.Parapsilosis分离物。有趣的是，PG也存在于Caspofungin浓度相对较低的情况下。

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