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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399
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Cytotoxic anthracycline and antibacterial tirandamycin analogues from a marine-derived Streptomyces sp. SCSIO 41399

机译：来自海洋衍生的链霉菌SP的细胞毒性蒽环素和抗菌脂胺类似物。 SCSIO 41399.

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摘要

Aranciamycin K (1) and isotirandamycin B (2) were isolated from a marine-derived Streptomyces sp. SCSIO 41399, along with the previously reported four anthracycline derivatives (3-6), and two known tirandamycin derivatives (7 and 8). Their structures including absolute configurations were determined by extensive analysis of their spectroscopic analysis and ECD calculation method. Most of the isolated compounds were tested for their cytotoxic, antibacterial, and antifungal activities. Compounds 2, 7 and 8 displayed potent bacteriostatic effects against Streptococcus agalactiae with MIC values of 11.5, 5.9 and 5.7 mu M, respectively. Besides, compounds 3, 5 and 6 exhibited moderate in vitro cytotoxic activities against the K562 cell lines with IC(50 )values of 22.0 +/- 0.20, 1.80 +/- 0.01 and 12.1 +/- 0.07 mu M, respectively.
机译：阿甘霉素K（1）和伊替金刚素B（2）与海洋衍生的链霉菌SP分离。 SCSIO 41399以及先前报道的四种蒽环素衍生物（3-6）和两种已知的Tirandamycin衍生物（7和8）。 它们的结构包括绝对配置，通过广泛分析它们的光谱分析和ECD计算方法来确定。 测试大多数分离的化合物用于其细胞毒性，抗菌和抗真菌活性。 化合物2,7和8分别显示出对氨基酰胺的有效的抑菌作用，分别具有11.5,5.9和5.7μm的MIC值。 此外，化合物3,5和6分别对K562细胞系具有中度体外细胞毒性活性，IC（50）的IC（50）值分别为22.0 +/- 0.20,1.80 +/- 0.01和12.1 +/-0.07μm。

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  • 作者

    Cong Ziwen; Huang Xiaolong; Liu Yunhao; Liu Yuxuan; Wang Pei; Liao Shengrong; Yang Bin; Zhou Xuefeng; Huang Dongyi; Wang Junfeng;

  • 作者单位

    Chinese Acad Sci South China Sea Inst Oceanol RNAM Ctr Marine Microbiol Guangdong Key Lab Marine;

    Hainan Univ Inst Trop Agr &

    Forestry Haikou 570228 Hainan Peoples R China;

    Chinese Acad Sci South China Sea Inst Oceanol RNAM Ctr Marine Microbiol Guangdong Key Lab Marine;

    Chinese Acad Sci South China Sea Inst Oceanol RNAM Ctr Marine Microbiol Guangdong Key Lab Marine;

    Chinese Acad Trop Agr Sci Inst Trop Biosci &

    Biotechnol Minist Agr Key Lab Biol &

    Genet;

    Chinese Acad Sci South China Sea Inst Oceanol RNAM Ctr Marine Microbiol Guangdong Key Lab Marine;

    Chinese Acad Sci South China Sea Inst Oceanol RNAM Ctr Marine Microbiol Guangdong Key Lab Marine;

    Chinese Acad Sci South China Sea Inst Oceanol RNAM Ctr Marine Microbiol Guangdong Key Lab Marine;

    Hainan Univ Inst Trop Agr &

    Forestry Haikou 570228 Hainan Peoples R China;

    Chinese Acad Sci South China Sea Inst Oceanol RNAM Ctr Marine Microbiol Guangdong Key Lab Marine;

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  • 正文语种 eng
  • 中图分类 药学;
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