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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Hispidulones A and B, two new phenalenone analogs from desert plant endophytic fungus Chaetosphaeronema hispidulum
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Hispidulones A and B, two new phenalenone analogs from desert plant endophytic fungus Chaetosphaeronema hispidulum

机译：Hyspidulons A和B，来自沙漠植物内生真菌的两种新的酚醛类似物的鸡血糖肿瘤痣

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摘要

Two new phenalenone analogs hispidulones A (1) and B (2) were isolated from the specially bioenvironmental desert plant endophytic fungus Chaetosphaeronema hispidulum. The structure of these two compounds were elucidated by extensive spectra analysis including HR-ESI-MS, NMR (1H, 13C, 1H–1H COSY, HSQC, and HMBC), CD, and electronic circular dichroism (ECD) combined with quantum-chemical calculations adopting time-dependent density functional theory (TDDFT) approaches. The W long-ranged 1H–1H COSY and HMBC correlations are very important in the structural elucidation of these two compounds. Hispidulone A (1) possesses a cyclohexa-2,5-dien-1-one moiety, whereas hispidulone B (2) contains a hemiacetal OCH3 group, which are very rare in the structures of phenalenone analogs. According to structural features of these two compounds together considering the literature, the possible biosynthetic pathway of 1 and 2 was postulated. Hispidulone B (2) displayed cytotoxic activities against three cancer cell lines A549, Huh7, and HeLa with IC50 values of 2.71?±?0.08, 22.93?±?1.61, and 23.94?±?0.33?μM.
机译：两种新的酚烯酮类似物Hispidulons A（1）和B（2）与特殊的生物环境沙漠植物内科菌Chaetosphaeronema Hispidulum分离出来。通过广泛的光谱分析，包括HR-ESI-MS，NMR（1H，13,13C，1H-1H-1HS，HSQC和HMBC），CD和电子圆形二色性（ECD）与量子化学的广泛的光谱分析，阐明了这两种化合物的结构采用时间依赖性密度泛函理论（TDDFT）方法的计算。 W长范围的1H-1H舒适和HMBC相关性在这两种化合物的结构阐明中非常重要。 Hispidulone A（1）具有环己-2,5-DIEN-1-一组部分，而Hyspidulone B（2）含有半缩醛OCH3基团，其在酚烯酮类似物的结构中非常罕见。根据这两种化合物的结构特征在一起考虑文献，假设1和2的可能的生物合成途径。 Hyspidulone B（2）针对三种癌细胞系A549，HUH7和HeLa显示细胞毒性活动，IC50值为2.71±0.08,22.93？±α≤1.61和23.94？±0.33ΩΩ0.3.94μm。

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