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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Khatmiamycin, a motility inhibitor and zoosporicide against the grapevine downy mildew pathogen Plasmopara viticola from Streptomyces sp. ANK313.
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Khatmiamycin, a motility inhibitor and zoosporicide against the grapevine downy mildew pathogen Plasmopara viticola from Streptomyces sp. ANK313.

机译：Khatmiamycin，一种运动抑制剂和动物孢子针对葡萄霜霉病病理疟原虫从Streptomyces sp的血管瘤viticola。 ANK313。

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摘要

In the course of our screening for anti-peronosporomycetal agents, we isolated a new compound khatmiamycin (1), together with five known metabolites, GTRI-02 (3), 4-ethyl-5-methyl-heptanamide (4), aloesaponarin II (5), LL-C10037alpha (6) and LL-C10037beta (7) from the culture broth of a terrestrial Streptomyces sp. ANK313. The structures of these metabolites were assigned on the basis of their spectroscopic data. Khatmiamycin (1) exhibited potent motility inhibitory (100%) and lytic (83+/-7%) activities against zoospores of the grapevine downy mildew pathogen Plasmopara viticola at 10 mug ml(-1), followed by compounds 5 (MIC 25 mug ml(-1)), 7, 6, 3 in the order of decreasing activity. Khatmiamycin (1) also showed potent antibacterial activity against Staphylococcus aureus and Streptomyces viridochromogenes (Tu57) by causing inhibition zones of 11 and 14 mm diameter, respectively, at the dose of 40 mug per disk. This is the first report on motility inhibitory and lytic activities of metabolites from a terrestrial Streptomyces species against the zoospores of downy mildew pathogen P. viticola.
机译：在我们对抗异孢子术代谢的筛选过程中，我们分离出一种新的化合物Khatmiamycin（1），以及五种已知的代谢物，GTRI-02（3），4-乙基-5-甲基 - 庚酰胺（4），Aloesaponarin II （5），LL-C10037Alpha（6）和LL-C10037β（7）来自陆生链霉菌SP的培养液。 ANK313。基于其光谱数据分配这些代谢物的结构。 Khatmiamycin（1）在10张杯子mug ml（-1）下，患有葡萄霜霉病病理plasmopara viticola的血清孢子的有效的运动抑制（100％）和裂解（83 +/- 7％）活性，然后是化合物5（Mic 25杯子M1（-1）），7,6,3按照减少的活性。 Khatmiamycin（1）还通过引起每盘40杯剂量的抑制区域，通过引起11和14mm直径的抑制区域，表现出对葡萄球菌和链霉菌的抗菌活性（TU57）的有效抗菌活性。这是来自对粪便霉菌属病原体P.Viticola动物孢子孢子孢子的陆地孢子菌种类的代谢物的动力抑制和裂解和裂解活动的第一份报告。

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