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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Antibiotic susceptibility of plant-derived lactic acid bacteria conferring health benefits to human
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Antibiotic susceptibility of plant-derived lactic acid bacteria conferring health benefits to human

机译：植物衍生的乳酸菌赋予人类健康益处的抗生素敏感性

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摘要

Lactic acid bacteria (LAB) confer health benefits to human when administered orally. We have recently isolated several species of LAB strains from plant sources, such as fruits, vegetables, flowers, and medicinal plants. Since antibiotics used to treat bacterial infection diseases induce the emergence of drug-resistant bacteria in intestinal microflora, it is important to evaluate the susceptibility of LAB strains to antibiotics to ensure the safety and security of processed foods. The aim of the present study is to determine the minimum inhibitory concentration (MIC) of antibiotics against several plant-derived LAB strains. When aminoglycoside antibiotics, such as streptomycin (SM), kanamycin (KM), and gentamicin (GM), were evaluated using LAB susceptibility test medium (LSM), the MIC was higher than when using Mueller-Hinton (MH) medium. Etest, which is an antibiotic susceptibility assay method consisting of a predefined gradient of antibiotic concentrations on a plastic strip, is used to determine the MIC of antibiotics world-wide. In the present study, we demonstrated that Etest was particularly valuable while testing LAB strains. We also show that the low susceptibility of the plant-derived LAB strains against each antibiotic tested is due to intrinsic resistance and not acquired resistance. This finding is based on the whole-genome sequence information reflecting the horizontal spread of the drug-resistance genes in the LAB strains.
机译：乳酸菌（实验室）在口服给药时对人类的健康益处。我们最近从植物来源分离了几种实验室菌株，如水果，蔬菜，花卉和药用植物。由于用于治疗细菌感染疾病的抗生素诱导肠道微生物中耐药细菌的出现，因此评估实验室菌株对抗生素的易感性，以确保加工食品的安全性和安全性。本研究的目的是确定针对几种植物衍生的实验室菌株的抗生素的最小抑制浓度（MIC）。使用实验室敏感性试验培养基（LSM）评估氨基糖苷抗生素，例如链霉素（SM），卡那霉素（KANAM）和庆大霉素（GM），MIC高于使用Mueller-Hinton（MH）培养基时。 ETEST，其是一种抗生素敏感性测定方法，其由塑料带上的抗生素浓度的预定级梯度组成，用于确定全世界抗生素的MIC。在目前的研究中，我们证明了在测试实验室菌株的同时特别有价值。我们还表明，植物衍生的实验室菌株对每种抗生素测试的低敏感性是由于固有抗性和未获得性阻力。该发现基于整个基因组序列信息，反映了实验室菌株中药物抗性基因的水平扩散。

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    Noda Masafumi; Danshiitsoodol Narandalai; Inoue Yusuke; Okamoto Tomoko; Sultana Nasrin; Sugiyama Masanori;

  • 作者单位

    Hiroshima Univ Dept Probiot Sci Prevent Med Grad Sch Biomed &

    Hlth Sci Minami Ku Kasumi 1-2-3;

    Hiroshima Univ Dept Probiot Sci Prevent Med Grad Sch Biomed &

    Hlth Sci Minami Ku Kasumi 1-2-3;

    Mitsui Sugar Co Ltd Chuo Ku Hakozaki Cho 36-2 Tokyo 1030015 Japan;

    Hiroshima Univ Dept Probiot Sci Prevent Med Grad Sch Biomed &

    Hlth Sci Minami Ku Kasumi 1-2-3;

    Hiroshima Univ Dept Probiot Sci Prevent Med Grad Sch Biomed &

    Hlth Sci Minami Ku Kasumi 1-2-3;

    Hiroshima Univ Dept Probiot Sci Prevent Med Grad Sch Biomed &

    Hlth Sci Minami Ku Kasumi 1-2-3;

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  • 正文语种 eng
  • 中图分类 药学;
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