Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes.

Inokoshi J; Kawamoto K; Takagi Y; Matsuhama M; Omura S; Tomoda H

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Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes.

机译：两种人酰基 - COA的表达：二酰基甘油酰基转移酶同工酶在酵母中的同工酶和微生物抑制剂对同工酶的选择性。

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摘要

Two isozymes for human acyl-coenzyme A:diacylglycerol acyltransferase (DGAT), DGAT1 and DGAT2, were independently expressed in DGAT-deficient Saccharomyces cerevisiae to establish DGAT1- and DGAT2-S. cerevisiae. The selectivity of DGAT inhibitors of natural origin towards the isozymes was assessed in enzyme assays using the microsomal fractions prepared from DGAT1- and DGAT2-S. cerevisiae. Amidepsines and xanthohumol inhibited DGAT1 and DGAT2 with similar potency, whereas roselipins were found to inhibit DGAT2 selectively.

机译：用于人酰基 - 辅酶A：二酰基甘油酰基转移酶（DGAT），DGAT1和DGAT2的两种同工酶在DGAT缺陷型酿酒酵母中独立地表达，以建立DGAT1和DGAT2-S。酿酒酵母。使用由DGAT1和DGAT2-S制备的微粒体级分来评估天然来源的DGAT抑制剂的选择性朝向同工酶。酿酒酵母。酰胺和xanthohumol抑制具有相似效力的DGAT1和DGAT2，而发现Roselipins选择性地抑制DGAT2。

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《The Journal of Antibiotics: An International Journal》 |2009年第1期|共4页
作者
Inokoshi J; Kawamoto K; Takagi Y; Matsuhama M; Omura S; Tomoda H;
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School of Pharmacy Kitasato University Tokyo Japan.;

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正文语种 eng
中图分类药学;
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1. Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes. [J] . Inokoshi J, Kawamoto K, Takagi Y, The Journal of Antibiotics: An International Journal . 2009,第1期

机译：两种人酰基辅酶A：二酰基甘油酰基转移酶同工酶在酵母中的表达以及微生物抑制剂对同工酶的选择性。
2. Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes. [J] . Inokoshi J, Kawamoto K, Takagi Y, The Journal of Antibiotics: An International Journal . 2009,第1期

机译：两种人酰基 - COA的表达：二酰基甘油酰基转移酶同工酶在酵母中的同工酶和微生物抑制剂对同工酶的选择性。
3. Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes. [J] . Inokoshi J, Kawamoto K, Takagi Y, The Journal of Antibiotics: An International Journal . 2009,第1期

机译：两种人酰基 - COA的表达：二酰基甘油酰基转移酶同工酶在酵母中的同工酶和微生物抑制剂对同工酶的选择性。
4. INSIGHTS INTO THE STRUCTURE AND function OF ACYL-CoA: DIACYLGLYCEROL ACYLTRANSFERASE [C] . RODRIGO M.P. SILOTO, QIN LIU, RANDALL J. WESELAKE, International Symposium on Biocatalysis and Biotechnology . 2010

机译：酰基 - CoA的结构和功能见解：二酰基甘油酰基转移酶
5. Functional and Topological Analysis of Acyl-CoA:Diacylglycerol Acyltransferase 2 From Saccharomyces cerevisiae [D] . Liu, Qin 2011

机译：酿酒酵母中酰基辅酶A：二酰基甘油酰基转移酶2的功能和拓扑分析
6. Identification and characterization of DGA2 an acyltransferase of the DGAT1 acyl-CoA:diacylglycerol acyltransferase family in the oleaginous yeast Yarrowia lipolytica. New insights into the storage lipid metabolism of oleaginous yeasts [O] . Athanasios Beopoulos, Ramdane Haddouche, Philomene Kabran, -1

机译：DGA2的鉴定和表征DGA2是油性酵母解脂耶氏酵母中的DGAT1酰基辅酶A：二酰基甘油酰基转移酶家族的酰基转移酶。含油酵母储脂代谢的新见解
7. Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes [O] . Junji Inokoshi, Kyosuke Kawamoto, Yoichi Takagi, 2009

机译：两种人酰基 - COA的表达：二酰基甘油酰基转移酶同工酶在酵母中和微生物抑制剂对同工酶的选择性

Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes.

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