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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Antibacterial effect of antibiotic-loaded SBA-15 on biofilm formation by Staphylococcus aureus and Staphylococcus epidermidis
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Antibacterial effect of antibiotic-loaded SBA-15 on biofilm formation by Staphylococcus aureus and Staphylococcus epidermidis

机译：用金黄色葡萄球菌和金黄色葡萄球菌形成生物膜形成的抗菌作用

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摘要

Staphylococcus aureus and Staphylococcus epidermidis are human pathogens involved in implant-related infections. During those diseases, they are able to form biofilms showing resistance to the effect of many different antibiotics. Drug delivery systems allow a local and effective delivery of antibiotics at high concentrations in the infected tissue without causing the cytotoxic effects commonly linked to systemic administration. We report the use of a porous ceramic biomaterial, such as SBA-15 loaded with antibiotics, to deliver them directly to the infected tissue. SBA-15 discs were loaded with Vancomycin, Rifampin and a combination of both, introduced in a suspension of S. aureus 15981 and S. epidermidis ATCC 35984 and incubated during 6 and 24 h. A statistically significant decrease in the biofilm density and the number of viable bacteria was detected for all antibiotics at 6 h in both bacteria. Rifampin showed an increase in the biofilm density and the number of viable bacteria at 24 h. No differences were detected between Vancomycin and the combination of antibiotics. S. epidermidis was more sensitive to the effect of the antibiotics than S. aureus. Here we have demonstrated that SBA-15 is able to act as an effective drug delivery system not only from a pharmaceutical point of view, but also from a biological one.
机译：金黄色葡萄球菌和金黄色葡萄球菌是有关植入物相关感染的人病原体。在这些疾病期间，它们能够形成患者对许多不同抗生素的效果的抵抗力的生物膜。药物递送系统允许在感染组织中的高浓度下局部和有效地递送抗生素，而不会导致与全身给药有关的细胞毒性作用。我们报告使用多孔陶瓷生物材料，例如含有抗生素的SBA-15，将它们直接递送到受感染的组织。 SBA-15椎间盘用Vancomycin，利福平和两者的组合装载，所述两者的组合引入了S.UUREUS 15981和S.Peidermidis ATCC 35984的悬浮液中，并在6和24小时期间培养。在两种细菌中，在6小时内检测到生物膜密度的统计学上显着降低和可行性细菌的数量。利福平显示出生物膜密度的增加和24小时的活细菌数量。 Vancomycin之间没有差异和抗生素的组合。 S. Epidermidis对抗生素的影响比S. aureus更敏感。在这里，我们证明了SBA-15不仅可以作为有效的药物递送系统，不仅可以从药物的角度来看，而且可以从生物学中作用。

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