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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis
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Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis

机译：伊维菌素对生物骨骼的疗效，血吸虫病的中间宿主蜗牛载体

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摘要

The impact of ivermectin on adult snails of the genus Biomphalaria (B. glabrata, B. tenagophila and B. straminea), B. glabrata infected with Schistosoma mansoni, snail egg-masses cercariae and miracidia, as well as on guppy fish ( Poecilia reticulata) was examined and evaluated. Biomphalaria snails, egg-masses, parasite stages and guppies were all exposed to different concentrations of ivermectin for 24 h, followed by regular observations of mortality. The calculated lethal doses of ivermectin were around an LD50 of 0.03 mu g ml(-1), and an LD90 of 0.3 mu g ml(-1) for the three species of snails. Specimens of B. glabrata actually shedding parasite cercariae all died when exposed to ivermectin at a concentration of a mere 0.01 mu g ml(-1). Ivermectin B-1a, the major (80%) component of commercially available ivermectin, proved to be inactive, and it was the minor (20%) component, ivermectin B-1b, which caused snail death. Snail egg-masses were not affected, even at the highest concentration of 100 mu g ml(-1). With respect to S. mansoni parasite stages, 0.2 mu g ml(-1) ivermectin killed 50% of cercariae and miracidia within five minutes, rising to 90% after 30 min. Mortality of guppy fish within 24 h of exposure to ivermectin at concentrations of 0.5 mu g ml(-1) and 0.01 mu g ml(-1), were 100% and 30%, respectively. The concentration of 0.01 mu g ml(-1) that killed Schistosoma mansoni-infected snails only caused 30% mortality in guppy fish. Ivermectin can be considered a promising molluscicide, especially as it is more potent against infected snails than uninfected ones, although it has no impact on egg-masses. Ivermectin and its derivatives could be explored in the search for a new agent to help control schistosomiasis transmission.
机译：Ivermectin对生物骨髓属的成人蜗牛的影响（B.Glabrata，B. Tenagophila和B. Straminea），B.Glabrata感染血吸虫曼逊，蜗牛蛋群植物和米拉西亚，以及普遍的鱼类（Poecilia TeariCulata ）被检查和评估。 Biomphalaria蜗牛，蛋群，寄生虫阶段和突然暴露于24小时的不同浓度的伊维菌素，然后定期观察死亡率。计算的致命剂量的伊维菌素为0.03μgml（-1）的LD50，以及用于三种蜗牛的0.3μgml（-1）的LD90。 B.Glabrata的标本实际上脱落寄生虫胰岛素，当暴露于Ivermectin时，均为仅0.01μmgml（-1）的浓度。 Ivermectin B-1a，商业上可获得的Ivermectin的主要（80％）组分被证明是无活性的，并且它是次要（20％）组分，Ivermectin B-1b，导致蜗牛死亡。蜗牛蛋质量没有受到影响，即使以最高浓度为100 mu g ml（-1）。关于S. Mansoni寄生虫阶段，0.2μgml（-1）伊维菌素在五分钟内杀死50％的植绒素和miracidia，30分钟后升至90％。在0.5μgml（-1）浓度为0.5μg（-1）和0.01μmgml（-1）的浓度下暴露于伊维菌素的24小时内的蛋白蛋白的死亡率分别为100％和30％。杀死血吸虫的浓度为0.01μmgml（-1）感染血症感染的蜗牛只引起了30％的橘子鱼的死亡率。伊维菌素可被认为是一种有希望的软体动物，特别是因为它比未感染的蜗牛更有效，但它对蛋群没有影响。伊维菌素及其衍生物可以在寻找新试剂中探索，以帮助控制血吸虫病传播。

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