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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Trienylfuranol A and trienylfuranone A-B: metabolites isolated from an endophytic fungus, Hypoxylon submoniticulosum, in the raspberry Rubus idaeus
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Trienylfuranol A and trienylfuranone A-B: metabolites isolated from an endophytic fungus, Hypoxylon submoniticulosum, in the raspberry Rubus idaeus

机译：三苯基呋喃醇A和三苯基呋喃酮A-B：从覆盆子毛细血管中，从内生真菌，鼠尾草Imbus Idaeus中分离的代谢物

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摘要

A strain of Hypoxylon submonticulosum was isolated as an endophyte from a surface-sterilized leaf of a cultivated raspberry (Rubus idaeus). The liquid culture extract displayed growth inhibition activity against Saccharomyces cerevisiae using a disc diffusion assay. The extract's major component was identified as a new natural product, trienylfuranol A (1S,2S,4R)-1-((1'E,3'E)-hexa-1',3',5'-trieny1)-tetrahydro-4-methylfuran-2-ol (1), by high-resolution LC-MS and 1D and 2D NMR spectroscopy. Two additional new metabolites, trienylfuranones A (2) and B (3), were isolated as minor components of the extract and their structure elucidation revealed that they were biosynthetically related to 1. Absolute stereochemical configurations of compounds 1-3 were confirmed by NOE NMR experiments and by the preparation of Mosher esters. Complete hydrogenation of 1 yielded tetrahydrofuran 7 that was used for stereochemical characterization and assessment of antifungal activity.
机译：从培养的覆盆子（Rubus Idaeus）的表面灭菌的叶子中分离出一种低氧聚合物底粒子的菌株。 液体培养提取物使用盘扩散测定展示针对酿酒酵母的生长抑制活性。 提取物的主要组分被鉴定为新的天然产物，三苯基呋喃醇A（1s，2s，4r）-1 - （（1'e，3'e）-hexa-1'，3'，5'-trieny1）-tethydro -4-甲基呋喃-2-醇（1），通过高分辨率LC-MS和1D和2D NMR光谱。 分离出两种额外的新代谢物，三苯基呋喃酮A（2）和B（3），作为提取物的次要组分，其结构阐明显示它们与1.通过NOE NMR确认化合物1-3的绝对立体化学配置。NMR证实了化合物1-3的绝对立体化学配置 实验及其制备Mosher酯。 完全氢化1产生的四氢呋喃7，用于立体化学表征和抗真菌活性的评估。

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