Spoxazomicins A-C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460(T).

Inahashi Y; Iwatsuki M; Ishiyama A; Namatame M; Nishihara Tsukashima A; Matsumoto A; Hirose T; Sunazuka T; Yamada H; Otoguro K; Takahashi Y; Omura S; Shiomi K

首页> 外文期刊>The Journal of Antibiotics: An International Journal >Spoxazomicins A-C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460(T).

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Spoxazomicins A-C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460(T).

机译：Spoxazomicins A-C，由内胚菌孢子瘤产生的新型抗酸酯生物碱，孢子囊孢囊蛋白质K07-0460（T）。

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Three novel antitrypanosomal alkaloids, named spoxazomicins A-C, were isolated by silica gel column chromatography and HPLC from the culture broth of a new endophytic actinomycete species, Streptosporangium oxazolinicum K07-0460(T). The structures of the spoxazomicins were elucidated by NMR and X-ray crystal analyses and shown to be new types of pyochelin family antibiotic. Spoxazomicin A showed potent and selective antitrypanosomal activity with an IC value of 0.11 mug ml(1) in vitro without cytotoxicity against MRC-5 cells (IC=27.8 mug ml(1)).

机译：通过硅胶柱色谱法和HPLC分离出一种名为Spoxazomicins A-C的三种新的抗酸拷贝类生物碱，并从新的内生放射瘤物种的培养液中分离出来的血糖孢子蛋白，葵孢囊孢唑啉K07-0460（t）。通过NMR和X射线晶体分析阐明了氧化株毒素的结构，并显示为新型的脂肪酸家族抗生素。 Spoxazomicin A显示出效率和选择性抗糖基因组体活性，其在体外具有0.11麦克约ML（1）的IC值，没有细胞毒性抵御MRC-5细胞（IC = 27.8杯MAG mL（1））。

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《The Journal of Antibiotics: An International Journal》 |2011年第4期|共5页
作者
Inahashi Y; Iwatsuki M; Ishiyama A; Namatame M; Nishihara Tsukashima A; Matsumoto A; Hirose T; Sunazuka T; Yamada H; Otoguro K; Takahashi Y; Omura S; Shiomi K;
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Graduate School of Infection Control Sciences Kitasato University Tokyo Japan.;

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正文语种 eng
中图分类药学;
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1. Spoxazomicins A-C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460(T). [J] . Inahashi Y, Iwatsuki M, Ishiyama A, The Journal of Antibiotics: An International Journal . 2011,第4期

机译：Spoxazomicins A-C，一种由内生放线菌，草酸Streptosporangium oxazolinicum K07-0460（T）生产的新型抗锥虫生物碱。
2. Spoxazomicins A-C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460(T). [J] . Inahashi Y, Iwatsuki M, Ishiyama A, The Journal of Antibiotics: An International Journal . 2011,第4期

机译：Spoxazomicins A-C，由内胚菌孢子瘤产生的新型抗酸酯生物碱，孢子囊孢囊蛋白质K07-0460（T）。
3. Spoxazomicins A-C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460(T). [J] . Inahashi Y, Iwatsuki M, Ishiyama A, The Journal of Antibiotics: An International Journal . 2011,第4期

机译：Spoxazomicins A-C，由内胚菌孢子瘤产生的新型抗酸酯生物碱，孢子囊孢囊蛋白质K07-0460（T）。
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Spoxazomicins A-C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460(T).

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