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首页> 外文期刊>The Journal of Antibiotics: An International Journal >Clonocoprogens A, B and C, new antimalarial coprogens from the Okinawan fungus Clonostachys compactiuscula FKR-0021
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Clonocoprogens A, B and C, new antimalarial coprogens from the Okinawan fungus Clonostachys compactiuscula FKR-0021

机译:Clonocoprogens A,B和C,来自冲绳菌菌Clonostachys Compariuscula fkR-0021的新抗疟糖精

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摘要

Three new antimalarial compounds, clonocoprogens A, B, and C, were isolated from the static culture of an Okinawan fungus, Clonostachys compactiuscula FKR-0021. These compounds were new analogs of N-14-palmitoylcoprogen, reported as a siderophore. They showed moderate antimalarial activity against chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains, with IC50 values ranging from 1.7 to 9.9 mu M.
机译:三种新的抗疟剂化合物,Clonocoprogens A,B和C分离出静电培养物,Clonostachys CompariScula FKR-0021。 这些化合物是N-14-palmitoylcoprogen的新类似物,作为纵向载体。 它们表现出对抗氯喹敏和氯喹抗疟原虫菌株的适度抗疟活性,IC50值范围为1.7至9.9亩。

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    Kitasato Univ Grad Sch Infect Control Sci Minato Ku 5-9-1 Shirokane Tokyo 1088641 Japan;

    Kitasato Univ Kitasato Inst Life Sci Minato Ku 5-9-1 Shirokane Tokyo 1088641 Japan;

    Kitasato Univ Grad Sch Infect Control Sci Minato Ku 5-9-1 Shirokane Tokyo 1088641 Japan;

    Kitasato Univ Kitasato Inst Life Sci Minato Ku 5-9-1 Shirokane Tokyo 1088641 Japan;

    Kitasato Univ Kitasato Inst Life Sci Minato Ku 5-9-1 Shirokane Tokyo 1088641 Japan;

    Kitasato Univ Kitasato Inst Life Sci Minato Ku 5-9-1 Shirokane Tokyo 1088641 Japan;

    Kitasato Univ Kitasato Inst Life Sci Minato Ku 5-9-1 Shirokane Tokyo 1088641 Japan;

    Kitasato Univ Grad Sch Infect Control Sci Minato Ku 5-9-1 Shirokane Tokyo 1088641 Japan;

    Kitasato Univ Grad Sch Sci Minami Ku 1-15-1 Kitazato Sagamihara Kanagawa 2520373 Japan;

    Kitasato Univ Kitasato Inst Life Sci Minato Ku 5-9-1 Shirokane Tokyo 1088641 Japan;

    Kitasato Univ Grad Sch Infect Control Sci Minato Ku 5-9-1 Shirokane Tokyo 1088641 Japan;

    Kitasato Univ Grad Sch Infect Control Sci Minato Ku 5-9-1 Shirokane Tokyo 1088641 Japan;

    Univ Ryukyus Fac Agr Senbaru 1 Nishihara Okinawa 9030213 Japan;

    Univ Ryukyus Fac Educ 1 Senbaru Nishihara Okinawa 9030213 Japan;

    Kitasato Univ Grad Sch Infect Control Sci Minato Ku 5-9-1 Shirokane Tokyo 1088641 Japan;

    Kitasato Univ Kitasato Inst Life Sci Minato Ku 5-9-1 Shirokane Tokyo 1088641 Japan;

    Kitasato Univ Kitasato Inst Life Sci Minato Ku 5-9-1 Shirokane Tokyo 1088641 Japan;

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  • 正文语种 eng
  • 中图分类 药学;
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