Complete NMR assignment and absolute configuration of k4610422, a norditerpenoid inhibitor of testosterone-5α-reductase originally from Streptosporangium: rediscovery from a thermophilic Actinomadura

Hirofumi Akiyama

首页> 外文期刊>The Journal of Antibiotics: An International Journal >Complete NMR assignment and absolute configuration of k4610422, a norditerpenoid inhibitor of testosterone-5α-reductase originally from Streptosporangium: rediscovery from a thermophilic Actinomadura

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Complete NMR assignment and absolute configuration of k4610422, a norditerpenoid inhibitor of testosterone-5α-reductase originally from Streptosporangium: rediscovery from a thermophilic Actinomadura

机译：最初来自链孢子孢子段的睾酮-5α-还原酶的Norditerpenoid抑制剂的完整NMR分配和绝对配置：从嗜热Actinomadura重新发现

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A norditerpenoid k4610422 (1), an inhibitor of testosterone-5α-reductase originally discovered from a mesophilic rare actinomycete of the genus Streptosporangium, was isolated from the culture extract of a thermophilic actinomycete Actinomadura sp. The complete 1H and 13C NMR assignment and absolute configuration of 1 were addressed by spectroscopic measurements including NOESY and CD spectra coupled with ECD calculation, which allowed to establish the (5?R,9?S,10?R,13?S)-configuration. Compound 1 was moderately cytotoxic against P388 murine leukemia cells with IC50 30 μM.

机译：从嗜热放射素腺嘌呤腺嘌呤Sp的培养提取物中分离出原始地发现的睾酮-5α-还原酶的抑制剂-5α-还原酶的抑制剂。通过光谱测量来解决完整的1H和13C NMR分配和1的绝对配置，包括NOESY和CD光谱，与ECD计算耦合，允许建立（5？R，9？S，10≤R，13Ω） - 配置。化合物1对具有IC5030μm的P388鼠白血病细胞中适度细胞毒性。

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《The Journal of Antibiotics: An International Journal》 |2020年第1期|共6页
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Hirofumi Akiyama;
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中图分类药学;
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1. Complete NMR assignment and absolute configuration of k4610422, a norditerpenoid inhibitor of testosterone-5α-reductase originally from Streptosporangium: rediscovery from a thermophilic Actinomadura [J] . Hirofumi Akiyama The Journal of Antibiotics: An International Journal . 2020,第1期

机译：最初来自链孢子孢子段的睾酮-5α-还原酶的Norditerpenoid抑制剂的完整NMR分配和绝对配置：从嗜热Actinomadura重新发现
2. Absolute configuration and complete assignment of C-13 NMR data for new sesquiterpenes from Maytenus chiapensis [J] . Nunez MJ, Cortes-Selva F, Bazzocchi IL, Journal of natural products . 2003,第4期

机译：来自Maytenus chiapensis的新倍半萜的绝对构型和C-13 NMR数据的完全分配
3. Assignment of the absolute configuration of hepatoprotective highly oxygenated triterpenoids using X-ray, ECD, NMR J -based configurational analysis and HSQC overlay experiments [J] . Xiaojuan Wang, Jiabao Liu, Pankaj Pandey, Biochimica et Biophysica Acta. General Subjects . 2017,第12期

机译：使用X射线，ECD，NMR J基础配置分析和HSQC覆盖实验分配HepatoPotective高度含氧三萜类化合物的绝对构型
4. Assignment of the absolute configuration of hepatoprotective highly oxygenated triterpenoids using X-ray ECD NMR J-based configurational analysis and HSQC overlay experiments [O] . Xiaojuan Wang, Jiabao Liu, Pankaj Pandey, -1

机译：使用X射线ECD基于NMR J的构型分析和HSQC覆盖实验指定对肝保护性高度氧化的三萜类化合物的绝对构型
5. Crystal Structure of a 1:1 Complex of Natural Diterpenoids: Absolute Configurations and Unambiguous NMR Spectral Assignments of Neoangustifolin and Epinodosinol [O] . Han−Dong Sun, Long-Ze Lin, Rong-Ping Zhang, 1997

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Complete NMR assignment and absolute configuration of k4610422, a norditerpenoid inhibitor of testosterone-5α-reductase originally from Streptosporangium: rediscovery from a thermophilic Actinomadura

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