GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin- resistant S. aureus

Qi Xin; Li Xiaoqian; Zhao Jianyuan; He Ning; Li Yihong; Zhang Tao; Wang Shanshan; Yu Liyan; Xie Yunying

首页> 外文期刊>The Journal of Antibiotics: An International Journal >GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin- resistant S. aureus

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GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin- resistant S. aureus

机译：GKK1032C，来自内科菌的新生物碱化合物Sp。 CPCC 400817含有针对甲氧西林的金黄色葡萄球菌的活性

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Five alkaloid compounds (1-5), including one new compound, GKK1032C (1), and four known compounds, pyrrospirones E (2) and F (3), and GKK1032B (4) and A2 (5) were isolated from the culture of endophytic fungus Penicillium sp. CPCC 400817. The planar structures of all compounds were elucidated by NMR and MS spectra. The relative configuration of new compound GKK1032C (1) was deduced from the vicinal J-values and ROESY spectral data. Compound 1 exhibited potent antibacterial activity against methicillin-resistant Staphylococcus aureus with an MIC value of 1.6 mu g ml(-1).

机译：从培养物中分离出五种生物碱化合物（1-5），包括一种新的化合物，GKK1032C（1）和四种已知的化合物，Pyrrospironese（2）和F（3）和GKK1032B（4）和GKK1032B（4）和A2（5）内生真菌青霉素sp。 CPCC 400817。通过NMR和MS光谱阐明了所有化合物的平面结构。从静脉J值和Roesy光谱数据中推导出新化合物GKK1032C（1）的相对配置。化合物1表现出抗甲氧西林耐金黄色葡萄球菌的有效抗菌活性，MIC值为1.6μgmm（-1）。

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《The Journal of Antibiotics: An International Journal》 |2019年第4期|共4页
作者
Qi Xin; Li Xiaoqian; Zhao Jianyuan; He Ning; Li Yihong; Zhang Tao; Wang Shanshan; Yu Liyan; Xie Yunying;
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Chinese Acad Med Sci Inst Med Biotechnol CAMS Key Lab Synthet Biol Drug Innovat Beijing Peoples;

Chinese Acad Med Sci Inst Med Biotechnol CAMS Key Lab Synthet Biol Drug Innovat Beijing Peoples;

Chinese Acad Med Sci Inst Med Biotechnol CAMS Key Lab Synthet Biol Drug Innovat Beijing Peoples;

Chinese Acad Med Sci Inst Med Biotechnol CAMS Key Lab Synthet Biol Drug Innovat Beijing Peoples;

Chinese Acad Med Sci Inst Med Biotechnol CAMS Key Lab Synthet Biol Drug Innovat Beijing Peoples;

Chinese Acad Med Sci Inst Med Biotechnol CAMS Key Lab Synthet Biol Drug Innovat Beijing Peoples;

Chinese Acad Med Sci Inst Med Biotechnol CAMS Key Lab Synthet Biol Drug Innovat Beijing Peoples;

Chinese Acad Med Sci Inst Med Biotechnol CAMS Key Lab Synthet Biol Drug Innovat Beijing Peoples;

Chinese Acad Med Sci Inst Med Biotechnol CAMS Key Lab Synthet Biol Drug Innovat Beijing Peoples;

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正文语种 eng
中图分类药学;
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1. GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin- resistant S. aureus [J] . Qi Xin, Li Xiaoqian, Zhao Jianyuan, The Journal of Antibiotics: An International Journal . 2019,第4期

机译：GKK1032C，来自内科菌的新生物碱化合物Sp。 CPCC 400817含有针对甲氧西林的金黄色葡萄球菌的活性
2. A New Terminal Cyano Group-containing Benzodiazepine Alkaloid from the Mangrove Endophytic Fungus Penicillium sp. [J] . Li Jing, Zhong Yi-sheng, Yuan Jie, Natural product communications . 2015,第9期

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4. Potential Antibacterial Activity of Endophytic Fungi Penicillium sp. and Trichoderma sp. Derived From Mangrove Ceriops Tagal (Perr.) C.B.Robb and Bruguiera sp. [C] . Yuli Haryani, Rahmiwati Hilma, Noviza Delfira, Universitas Riau International Conference on Science and Environment . 2020

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5. New and Bioactive Compounds from Penicillium concentricum , an Endophytic Fungus of the Liverwort Trichocolea tomentella [D] . Ali, Tehane A. Hamed. 2017

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机译：内生真菌青霉菌对银纳米颗粒的优化与表征分离自姜黄（姜黄）和抗MDR大肠杆菌和金黄色葡萄球菌的应用研究
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机译：内生真菌提取物的效果，对抗甲氧脲抗性的生长金黄色葡萄球菌的生长（MRSA）和肺炎肺炎

GKK1032C, a new alkaloid compound from the endophytic fungus Penicillium sp. CPCC 400817 with activity against methicillin- resistant S. aureus

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